Mouse Anti-VHL Recombinant Antibody (clone PT0230)
CAT#: VS3-CJ927
This product is a mouse antibody that recognizes human VHL.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31631/723_F1_2_selected.jpg
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Specifications
- Immunogen
- Synthesized peptide derived from human pVHL
- Host Species
- Mouse
- Type
- Mouse IgG3, κ
- Specificity
- Human VHL
- Species Reactivity
- Human
- Clone
- PT0230
- Applications
- IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- RCA1; VHL1; pVHL; HRCA1
- Gene ID
- 7428
- UniProt ID
- P40337
- Sequence Similarities
- Belongs to the VHL family.
- Cellular Localization
- Cytoplasm, Membrane, Nucleus
- Protein Refseq
- NP_000542.1; NP_937799.1
- Function
- Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
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Recommended Dilution Buffer
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- Product Name
See other products for "VHL"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4018z | Mouse Anti-VHL Recombinant Antibody (clone 38G11) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-2116CT | Recombinant Mouse anti-Human VHL Monoclonal antibody (4G402) | IHC-P, WB | |
| MOB-0233F | Mouse Anti-VHL Recombinant Antibody (MOB-0233F) | IHC-P, IF | Mouse IgG |
| VS3-CJ928 | Mouse Anti-VHL Recombinant Antibody (clone ABT-PVHL) | IHC-P | Mouse IgG2b, κ |
| VS3-FY1545 | Recombinant Mouse Anti-VHL Antibody (clone 3B1-8B7-4H3) | IHC-P | Mouse IgG3 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2469 | Anti-VHL Immunohistochemistry Kit | IHC | |
| VS-0525-XY7848 | Anti-Mouse VHL Immunohistochemistry Kit | IHC | |
| VS-0525-XY7847 | Anti-Human VHL Immunohistochemistry Kit | IHC |
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