Rabbit Anti-VPS41 Recombinant Antibody (clone R08-1J7)
CAT#: VS3-FY1937
This R08-1J7 recombinant monoclonal antibody is specifically created to target human VPS41. It cross-reacts with mouse, rat. This VPS41 antibody is guaranteed for western blot analysis of VPS41 in rat heart lysates.
Tested Data
Gene Expression
WB
Figure 1 Anti-VPS41 Antibody (VS3-FY1937) in WB.
The VPS41 expression in rat heart lysates were detected using the anti-VPS41 by western blot assay.
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Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity with a granular pattern in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20080/46207_A_8_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human esophagus
Immunohistochemical staining of human esophagus shows strong cytoplasmic positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20299/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20080/45771_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20080/46207_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20080/46207_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20080/46207_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20080/46207_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20080/46207_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000006715-VPS41
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Specifications
- Immunogen
- Synthetic peptide of human VPS41
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat VPS41
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-1J7
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 99 kDa, while the observed molecular weight stands at 99 kDa.
- Related Disease
- Spinocerebellar Ataxia, Autosomal Recessive 29 and Spinocerebellar Ataxia, Autosomal Recessive 4
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- VPS41, HOPS Complex Subunit; S53; Vacuolar Protein Sorting-Associated Protein 41 Homolog; Vacuolar Protein Sorting 41 Homolog (S. Cerevisiae); Vacuolar Protein Sorting 41 (Yeast Homolog); Vacuolar Protein Sorting 41 (Yeast)
- Gene ID
- 27072
- UniProt ID
- P49754
- Sequence Similarities
- Belongs to the VPS41 family.
- Cellular Localization
- Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane
- Post Translation Modifications
- Ubiquitination at Lys762 (NX_P49754 [NX_P49754-1])
Modification sites at PhosphoSitePlus (P49754)
Glycosylation from GlyGen (P49754) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016867477.1; XP_054213879.1; NP_055211.2; NP_542198.2
- Function
- Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Secondary Antibody
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See other products for "VPS41"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3850 | Rabbit Anti-VPS41 Recombinant Antibody (clone DS3850AB) | WB | Rabbit IgG |
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