Rabbit Anti-XPO4 Recombinant Antibody (clone R09-1A2) (CAT#: VS3-FY1711)

• Immunogen
• Synthetic peptide of human Exportin 4

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat XPO4

• Species Reactivity
• Human, Rat

• Clone
• R09-1A2

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 130 kDa, while the observed molecular weight stands at 130 kDa.

• Related Disease
• Enamel Erosion

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• Exportin 4; XPO4

• Gene ID
• 64328

• UniProt ID
• Q9C0E2

• Sequence Similarities
• Belongs to the exportin family.

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Phosphoprotein

• Protein Refseq
• XP_005266561.1; XP_011533502.1; XP_016876193.1; XP_016876194.1; XP_016876195.1

• Function
• Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2).
  In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.
  Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor.
  XPO4 then return to the nuclear compartment and mediate another round of transport.
  The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4.
  Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6.
  Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody