Rabbit Anti-XPO4 Recombinant Antibody (clone R09-1A2)
CAT#: VS3-FY1711
The R09-1A2 recombinant monoclonal antibody is specifically created to target human XPO4. It cross-reacts with rat. It is suitable for use in a variety of assays, including WB, IP. Applications Tested: The XPO4 antibody has been tested by western blot analysis of Exportin 4 in MCF-7, C6 lysates.
Tested Data
WB
Figure 1 Anti-XPO4 Antibody (VS3-FY1711) in WB.
The Exportin 4 expression in MCF-7, C6 lysates were detected using the anti-XPO4 by western blot assay.
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Specifications
- Immunogen
- Synthetic peptide of human Exportin 4
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat XPO4
- Species Reactivity
- Human, Rat
- Clone
- R09-1A2
- Applications
- Western Blot, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 130 kDa, while the observed molecular weight stands at 130 kDa.
- Related Disease
- Enamel Erosion
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunoprecipitation: 1/20
Target
- Alternative Names
- Exportin 4; XPO4
- Gene ID
- 64328
- UniProt ID
- Q9C0E2
- Sequence Similarities
- Belongs to the exportin family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Phosphoprotein
- Protein Refseq
- XP_005266561.1; XP_011533502.1; XP_016876193.1; XP_016876194.1; XP_016876195.1
- Function
- Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2).
In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.
Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor.
XPO4 then return to the nuclear compartment and mediate another round of transport.
The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4.
Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6.
Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
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