Rabbit Anti-YTHDF1 Recombinant Antibody (VS3-FY2925) (CAT#: VS3-FY2925)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Hamster YTHDF1

• Species Reactivity
• Human, Hamster

• Applications
• Western Blot, Immunoprecipitation

• Conjugate
• Unconjugated, FITC

• Related Disease
• Ocular Melanoma and Wilms Tumor 1

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunoprecipitation: 1/20
  Western Blot: 1/500-1/1000

• Alternative Names
• YTH N6-Methyladenosine RNA Binding Protein 1; Dermatomyositis Associated With Cancer Putative Autoantigen 1; YTH N(6)-Methyladenosine RNA Binding Protein 1; YTH Domain Family, Member 1; YTH Domain Family 1; C20orf21; DACA-1; YTH Domain-Containing Family Protein 1; YTH Domain Family Protein 1

• Gene ID
• 54915

• UniProt ID
• Q9BYJ9

• Sequence Similarities
• Belongs to the YTHDF family. YTHDF1 subfamily.

• Cellular Localization
• Cytoplasm
  Cytoplasm, P-body
  Cytoplasm, Stress granule

• Post Translation Modifications
• Glycosylation at Ser196 (NX_Q9BYJ9 [NX_Q9BYJ9-1])
  Modification sites at PhosphoSitePlus (Q9BYJ9)
  Glycosylation from GlyConnect YTHD1_HUMAN (2853)
  Glycosylation from GlyGen (Q9BYJ9) 15 sites, 2 O-linked glycans (15 sites)

• Protein Refseq
• XP_054179531.1; NP_060268.2

• Function
• Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408).
  The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, 32492408).
  Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity).
  Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity).
  Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity).

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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