Rabbit Anti-YTHDF1 Recombinant Antibody (VS3-FY2925)
CAT#: VS3-FY2925
The anti-YTHDF1 antibody is a rabbit recombinant monoclonal antibody that has been designed to bind the human YTHDF1 protein. It cross-reacts with hamster species. This monoclonal antibody proves valuable in disease research related to Ocular Melanoma and Wilms Tumor 1. The antibody can be utilized for detection of target protein by Immunoprecipitation (1/20), Western Blot (1/500-1/1000).
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Hamster YTHDF1
- Species Reactivity
- Human, Hamster
- Applications
- Western Blot, Immunoprecipitation
- Conjugate
- Unconjugated, FITC
- Related Disease
- Ocular Melanoma and Wilms Tumor 1
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Target
- Alternative Names
- YTH N6-Methyladenosine RNA Binding Protein 1; Dermatomyositis Associated With Cancer Putative Autoantigen 1; YTH N(6)-Methyladenosine RNA Binding Protein 1; YTH Domain Family, Member 1; YTH Domain Family 1; C20orf21; DACA-1; YTH Domain-Containing Family Protein 1; YTH Domain Family Protein 1
- Gene ID
- 54915
- UniProt ID
- Q9BYJ9
- Sequence Similarities
- Belongs to the YTHDF family. YTHDF1 subfamily.
- Cellular Localization
- Cytoplasm
Cytoplasm, P-body
Cytoplasm, Stress granule
- Post Translation Modifications
- Glycosylation at Ser196 (NX_Q9BYJ9 [NX_Q9BYJ9-1])
Modification sites at PhosphoSitePlus (Q9BYJ9)
Glycosylation from GlyConnect YTHD1_HUMAN (2853)
Glycosylation from GlyGen (Q9BYJ9) 15 sites, 2 O-linked glycans (15 sites)
- Protein Refseq
- XP_054179531.1; NP_060268.2
- Function
- Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408).
The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, 32492408).
Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity).
Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity).
Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "YTHDF1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1236 | Rabbit Anti-Ythdf1 Recombinant Antibody (VS13-YC1236) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2509 | Anti-YTHDF1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7985 | Anti-Human YTHDF1 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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