Anti-ZNRF3 Antibody Prodrug, Protease Activated (VS-1025-YC137)
CAT#: VS-1025-YC137
The Anti-ZNRF3 Antibody Prodrug, Protease Activated (VS-1025-YC137) is an antibody prodrug comprised of a recombinant human antibody targeting human ZNRF3, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to ZNRF3 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to ZNRF3 effectively. ZNRF3 is a transmembrane E3 ubiquitin ligase that acts as a key negative regulator and tumor suppressor of the Wnt signaling pathway. Inactivating mutations in ZNRF3 are recurrent in cancers like hepatocellular carcinoma and colorectal cancer, leading to the stabilization of Wnt receptors and unchecked Wnt/β-catenin signaling.
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human ZNRF3
- Target
- ZNRF3
- Species Reactivity
- Human
- Isotype
- IgG1, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 are negative regulators of β-catenin and the Wnt signaling pathway in eukaryotic cells. The activity of ZNRF3 can be modulated by antibody binding to its extracellular domain, thus causing an increase in Wnt signaling.
- Alternative Names
- ZNRF3; RNF203; BK747E2.3; Zinc and ring finger 3
- Gene ID
- 84133
- UniProt ID
- Q9ULT6
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-379CQ | Human Anti-ZNRF3 Recombinant Antibody (TAB-379CQ) | ELISA | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-380CQ | Human Anti-ZNRF3 Recombinant Antibody (TAB-380CQ) | ELISA | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-379CQ-S(P) | Human Anti-ZNRF3 Recombinant Antibody; scFv Fragment (TAB-379CQ-S(P)) | ELISA, FC, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-380CQ-S(P) | Human Anti-ZNRF3 Recombinant Antibody; scFv Fragment (TAB-380CQ-S(P)) | ELISA, FC, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-379CQ-F(E) | Human Anti-ZNRF3 Recombinant Antibody; Fab Fragment (TAB-379CQ-F(E)) | ELISA, FC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC166 | Recombinant Anti-ZNRF3 Vesicular Antibody, EV Displayed (VS-0425-YC166) | ELISA, FC, Cell-uptake |
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