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ZNRF3
Loading...Anti-ZNRF3 Products
- Human Anti-ZNRF3 Recombinant Antibody; Fab Fragment (TAB-379CQ-F(E)) (TAB-379CQ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, WB
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- Human Anti-ZNRF3 Recombinant Antibody; Fab Fragment (TAB-380CQ-F(E)) (TAB-380CQ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, WB
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- Human Anti-ZNRF3 Antibody, mRNA (TAB-675CL-mRNA)
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- Species Reactivity: Human
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For Research Use Only. Not For Clinical Use.
Background
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Protein class
Enzymes
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Astrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Hep G2)
Interaction
Interacts with LRP6, FZD4, FZD5, FZD6 and FZD8 (PubMed:22575959). Interacts with RSPO1; interaction promotes indirect interaction with LGR4 and membrane clearance of ZNRF3 (PubMed:22575959). Also interacts with RSPO2 (PubMed:29769720). Interacts with LMBR1L (PubMed:31073040).
Molecular function
Developmental protein, Transferase
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