ZNRF3
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Loading...- Human Anti-ZNRF3 Recombinant Antibody; Fab Fragment (TAB-379CQ-F(E)) (TAB-379CQ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, WB
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- Human Anti-ZNRF3 Recombinant Antibody; Fab Fragment (TAB-380CQ-F(E)) (TAB-380CQ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, WB
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- Human Anti-ZNRF3 Antibody, mRNA (TAB-675CL-mRNA)
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- Species Reactivity: Human
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- Species Reactivity: Human
- Target: ZNRF3
- Host Animal: Human
- Application: ELISA, FC, Cell-uptake
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- Anti-ZNRF3 Antibody Prodrug, Protease Activated (VS-1025-YC137) (VS-1025-YC137)
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- Species Reactivity: Human
- Host Animal: Human
- Target: ZNRF3
- Application: ISZ, Cyt, FuncS
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For Research Use Only. Not For Clinical Use.
Background
The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 are negative regulators of β-catenin and the Wnt signaling pathway in eukaryotic cells. The activity of ZNRF3 can be modulated by antibody binding to its extracellular domain, thus causing an increase in Wnt signaling.
Protein class
Enzymes
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Astrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Hep G2)
Interaction
Interacts with LRP6, FZD4, FZD5, FZD6 and FZD8 (PubMed:22575959). Interacts with RSPO1; interaction promotes indirect interaction with LGR4 and membrane clearance of ZNRF3 (PubMed:22575959). Also interacts with RSPO2 (PubMed:29769720). Interacts with LMBR1L (PubMed:31073040).
Molecular function
Developmental protein, Transferase
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