DRB1*01:01/HBV env (QAGFFLLTRILTIPQS) MHC Monomer
CAT#: MHC-YF076
This product is a MHC monomer of biotinylated peptide/MHC complex composed env-derived peptide of QAGFFLLTRILTIPQS sequence covering 179-194 and DRB1*01:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*01:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- env
- Antigen Species
- HBV
- Peptide
- QAGFFLLTRILTIPQS
- Range
- 179-194
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
- Alternative Names
- Large envelope protein; L glycoprotein; L-HBsAg; Large S protein; Large surface protein;Major surface antigen
- Gene ID
- 944569
- UniProt ID
- P03140
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