DRB1*01:01/HBV env (QAGFFLLTRILTIPQS) MHC Monomer
CAT#: MHC-YF076
This product is a MHC monomer of biotinylated peptide/MHC complex composed env-derived peptide of QAGFFLLTRILTIPQS sequence covering 179-194 and DRB1*01:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*01:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- env
- Antigen Species
- HBV
- Peptide
- QAGFFLLTRILTIPQS
- Range
- 179-194
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
- Alternative Names
- Large envelope protein; L glycoprotein; L-HBsAg; Large S protein; Large surface protein;Major surface antigen
- Gene ID
- 944569
- UniProt ID
- P03140
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Excellent HBV env Monomer
This biotinylated DRB1*01:01 monomer loaded with the HBV env peptide QAGFFLLTRILTIPQS was perfect for our needs. We used it to generate tetramers that successfully identified antigen-specific CD4 T cells in our research on Hepatitis B virus.
High Quality Viral Antigen Tool
We purchased this monomer to study immune responses to the large envelope protein of HBV. The product quality is high, ensuring efficient tetramerization and reliable detection of specific T cells in our immunological assays.
Q&As
-
What is the peptide sequence of the HBV env monomer?
A: The peptide sequence loaded onto this DRB1*01:01 monomer is QAGFFLLTRILTIPQS. It corresponds to amino acids 179-194 of the Hepatitis B virus envelope protein (S protein).
-
What does the label 'MHC Monomer' imply for the user?
A: 'MHC Monomer' implies that the product is a single peptide-MHC complex, usually biotinylated, that has not yet been oligomerized. The user must cross-link it, usually with streptavidin, to create a multimeric reagent suitable for stable T cell binding and detection.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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