DRB1*03:01/Human PLP (RQIFGDYKTTIC) MHC Monomer

CAT#: MHC-YF110

This product is a MHC monomer of biotinylated peptide/MHC complex composed PLP-derived peptide of RQIFGDYKTTIC sequence covering 98-109 and DRB1*03:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

Specifications

  • Allele
  • DRB1*03:01
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • PLP
  • Antigen Species
  • Human
  • Peptide
  • RQIFGDYKTTIC
  • Range
  • 98-109
  • Conjugate
  • Biotin

Target

  • Antigen Introduction
  • This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant.
  • Alternative Names
  • PLP; PMD; HLD1; MMPL; SPG2; GPM6C; PLP/DM20
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