DRB1*09:01/Mycobacterium tuberculosis Mtb ESAT6 (MTEQQWNFAGIEAAA) MHC Monomer

CAT#: MHC-YF128

This product is a MHC monomer of biotinylated peptide/MHC complex composed Mtb ESAT6-derived peptide of MTEQQWNFAGIEAAA sequence covering 1-15 and DRB1*09:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

Specifications

  • Allele
  • DRB1*09:01
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • Mtb ESAT6
  • Antigen Species
  • Mycobacterium tuberculosis
  • Peptide
  • MTEQQWNFAGIEAAA
  • Range
  • 1-15
  • Conjugate
  • Biotin

Target

  • Antigen Introduction
  • A secreted protein that plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. Acts as a strong host (human) T-cell antigen. Inhibits IL-12 p40 (IL12B) and TNF-alpha expression by infected host (mouse) macrophages, reduces the nitric oxide response by about 75%.
  • Alternative Names
  • 6 kDa early secretory antigenic target; ESAT-6; esxA; esaT6; Rv3875; MTV027.10
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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