Human Anti-CD200 scFv-Fc Chimera (VS-0425-FY81)
CAT#: VS-0425-FY81
This fusion protein targets CD200 (Ox2), an immunoregulatory molecule involved in modulating macrophage activity. It is being explored for its potential use in treating inflammatory and autoimmune conditions by inhibiting macrophage activation.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (AF22, HHSteC, NTERA-2, REH, SK-MEL-30, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091972-CD200
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Specifications
- Immunogen
- Human CD200 as an immunogen.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human CD200
- Species Reactivity
- Human
- Applications
- Blocking, ELISA
- Related Disease
- Penis Squamous Cell Carcinoma and Immune Defect Due To Absence Of Thymus
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: The EC₅₀ for this antibody is about 2 ng/mL.
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- CD200 Molecule; CD200 Antigen; Antigen Identified By Monoclonal Antibody MRC OX-2; MOX1; MOX2; OX-2 Membrane Glycoprotein; OX-2; MRC
- Gene ID
- 4345
- UniProt ID
- P41217
- Long Name
- CD200 Molecule
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn95, Asn103, Asn110, Asn157, Asn181, and Asn190
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 7 sites
- Protein Refseq
- NP_001004196.2; NP_001305755.1; NP_001305757.1; NP_001305759.1; NP_001352780.1
- Function
- Costimulates T-cell proliferation.
May regulate myeloid cell activity in a variety of tissues.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CD200"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1205z | Mouse Anti-CD200 Recombinant Antibody (clone 20C7) | FC, IHC, FuncS | Mouse IgG1 |
| MOB-2283MZ | Mouse Anti-CD200 Recombinant Antibody (clone NSD PY-3) | FC | Mouse IgG1 |
| HPAB-0259-YJ | Human Anti-CD200 Recombinant Antibody (HPAB-0259-YJ) | FC, ELISA, FuncS | Chimeric (Mouse/Human) IgG1, κ |
| HPAB-0260-YJ | Human Anti-CD200 Recombinant Antibody (HPAB-0260-YJ) | FC, ELISA, FuncS | Humanized IgG1, κ |
| VS-0723-WK246 | Rabbit Anti-CD200 Recombinant Antibody (VS-0723-WK246) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-210 | Anti-Human CD200 Recombinant Antibody (TAB-210) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG2 / G4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-302CQ | Mouse Anti-CD200 Recombinant Antibody (clone CBL014) | Neut | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-303CQ | Mouse Anti-CD200 Recombinant Antibody (clone OX-104) | FC, IHC, Block | Mouse IgG1, κ |
| NEUT-305CQ | Mouse Anti-CD200 Recombinant Antibody (clone CBL367) | ELISA, Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4025 | Hi-Affi™ Rabbit Anti-CD200 Recombinant Antibody (clone SI90DS) | IHC-P | Rabbit IgG |
| MOR-4026 | Hi-Affi™ Rabbit Anti-CD200 Recombinant Antibody (clone SI91DS) | FC | Rabbit IgG |
| MOR-4027 | Hi-Affi™ Rabbit Anti-CD200 Recombinant Antibody (clone SI92DS) | FC | Rabbit IgG |
| MOR-4028 | Hi-Affi™ Rabbit Anti-CD200 Recombinant Antibody (clone SI93DS) | ELISA | Rabbit IgG |
| MOR-4029 | Hi-Affi™ Rabbit Anti-CD200 Recombinant Antibody (clone SI94DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365LY-S(P) | Mouse Anti-CD200 Recombinant Antibody; scFv Fragment (HPAB-0365LY-S(P)) | IHC | Mouse scfv |
| HPAB-0259-YJ-S(P) | Mouse Anti-CD200 Recombinant Antibody; scFv Fragment (HPAB-0259-YJ-S(P)) | FC, ELISA, FuncS | Mouse scFv |
| HPAB-0260-YJ-S(P) | Human Anti-CD200 Recombinant Antibody; scFv Fragment (HPAB-0260-YJ-S(P)) | FC, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365LY-F(E) | Mouse Anti-CD200 Recombinant Antibody; Fab Fragment (HPAB-0365LY-F(E)) | IHC | Mouse Fab |
| HPAB-0259-YJ-F(E) | Human Anti-CD200 Recombinant Antibody; Fab Fragment (HPAB-0259-YJ-F(E)) | FC, ELISA, FuncS | Human Fab |
| HPAB-0260-YJ-F(E) | Human Anti-CD200 Recombinant Antibody; Fab Fragment (HPAB-0260-YJ-F(E)) | FC, ELISA, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-210 | Afuco™ Anti-CD200 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-210) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC212 | Recombinant Anti-CD200 Vesicular Antibody, EV Displayed (VS-0425-YC212) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1136 | Anti-CD200 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1137 | Anti-Rat CD200 Immunohistochemistry Kit | IHC |
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