Human Anti-CD200 scFv-Fc Chimera (VS-0425-FY81) (CAT#: VS-0425-FY81)
This fusion protein targets CD200 (Ox2), an immunoregulatory molecule involved in modulating macrophage activity. It is being explored for its potential use in treating inflammatory and autoimmune conditions by inhibiting macrophage activation.
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Custom Production
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Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_B_7_5.jpg
(Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_B_7_5.jpg
Figure 2 Colon
(Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_3.jpg
(Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_3.jpg
Figure 3 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_4.jpg
Figure 4 Kidney
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_8_5.jpg
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_8_5.jpg
Figure 5 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_5_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_5_6.jpg
Figure 6 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31149/64346_A_9_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (AF22, HHSteC, NTERA-2, REH, SK-MEL-30, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091972-CD200
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091972-CD200
Figure 7 RNA cell line category: Cell line enhanced (AF22, HHSteC, NTERA-2, REH, SK-MEL-30, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091972-CD200
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091972-CD200
Specifications
- Immunogen
- Human CD200 as an immunogen.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human CD200
- Species Reactivity
- Human
- Applications
- Blocking, ELISA
- Related Disease
- Penis Squamous Cell Carcinoma and Immune Defect Due To Absence Of Thymus
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: The EC₅₀ for this antibody is about 2 ng/mL.
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- CD200 Molecule; CD200 Antigen; Antigen Identified By Monoclonal Antibody MRC OX-2; MOX1; MOX2; OX-2 Membrane Glycoprotein; OX-2; MRC
- Gene ID
- 4345
- UniProt ID
- P41217
- Long Name
- CD200 Molecule
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn95, Asn103, Asn110, Asn157, Asn181, and Asn190
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 7 sites
- Protein Refseq
- NP_001004196.2; NP_001305755.1; NP_001305757.1; NP_001305759.1; NP_001352780.1
- Function
- Costimulates T-cell proliferation.
May regulate myeloid cell activity in a variety of tissues.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-210 | Anti-Human CD200 Recombinant Antibody (TAB-210) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG2 / G4 - kappa |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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