Human Anti-GPIb (clone HIb-6) scFv-Fc Chimera (CAT#: VS-0425-FY38)
The anti-GPIb scFv-Fc is a recombinant protein specifically designed to bind to the glycoprotein Ib (GPIb) receptor, which plays a critical role in platelet adhesion and activation. This product combines the unique abilities of single-chain variable fragments with the Fc domain of an antibody, allowing for enhanced stability and improved pharmacokinetics. With its high specificity for GPIb, this scFv-Fc construct can be utilized in studies targeting thrombotic disorders and other platelet-related conditions. The recombinant nature of this protein ensures consistent quality and shelf-life. Potential applications also include the development of diagnostic tools for platelet function assessment. Research is ongoing to explore its full therapeutic potential in treating cardiovascular complications.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Immunogen
- The immunogen is Chinese Hamster Ovary (CHO) cells expressing human platelet glycoprotein Ibα (GPIbα).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPIb
- Species Reactivity
- Human
- Clone
- HIb-6
- Applications
- Western Blot
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Glycoprotein Ib; GPIb; CD42b
- Long Name
- Glycoprotein Ib
- Function
- The GP1BA gene encodes the alpha subunit of glycoprotein Ib (GPIbα), a key component of the GPIb-IX-V complex found on the surface of platelets and megakaryocytes. This complex serves as the primary receptor for von Willebrand factor (VWF) in the initial adhesion of platelets to exposed subendothelium at sites of vascular injury under high shear stress conditions.
Upon binding to VWF, the GPIb-IX-V complex initiates platelet rolling and firm adhesion, a crucial first step in hemostasis and thrombus formation. Additionally, GPIbα contributes to platelet activation and signaling, playing a role in subsequent platelet aggregation and clot stabilization. Genetic defects in GP1BA can lead to bleeding disorders such as Bernard-Soulier syndrome, highlighting the gene's critical role in normal hemostatic function.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0913-WJ | Human Anti-GPIb Recombinant Antibody (clone SZ-138) | ELISA | Chimeric (mouse/human) IgG |
| HPAB-S0053-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-1) | WB | Human IgG |
| HPAB-S0054-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-2) | WB | Human IgG |
| HPAB-S0055-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-3) | WB | Human IgG |
| HPAB-S0056-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-5) | WB | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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