Human Anti-GPIb (clone HIb-6) scFv-Fc Chimera
CAT#: VS-0425-FY38
The anti-GPIb scFv-Fc is a recombinant protein specifically designed to bind to the glycoprotein Ib (GPIb) receptor, which plays a critical role in platelet adhesion and activation. This product combines the unique abilities of single-chain variable fragments with the Fc domain of an antibody, allowing for enhanced stability and improved pharmacokinetics. With its high specificity for GPIb, this scFv-Fc construct can be utilized in studies targeting thrombotic disorders and other platelet-related conditions. The recombinant nature of this protein ensures consistent quality and shelf-life. Potential applications also include the development of diagnostic tools for platelet function assessment. Research is ongoing to explore its full therapeutic potential in treating cardiovascular complications.
Specifications
- Immunogen
- The immunogen is Chinese Hamster Ovary (CHO) cells expressing human platelet glycoprotein Ibα (GPIbα).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPIb
- Species Reactivity
- Human
- Clone
- HIb-6
- Applications
- Western Blot
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Glycoprotein Ib; GPIb; CD42b
- Long Name
- Glycoprotein Ib
- Function
- The GP1BA gene encodes the alpha subunit of glycoprotein Ib (GPIbα), a key component of the GPIb-IX-V complex found on the surface of platelets and megakaryocytes. This complex serves as the primary receptor for von Willebrand factor (VWF) in the initial adhesion of platelets to exposed subendothelium at sites of vascular injury under high shear stress conditions.
Upon binding to VWF, the GPIb-IX-V complex initiates platelet rolling and firm adhesion, a crucial first step in hemostasis and thrombus formation. Additionally, GPIbα contributes to platelet activation and signaling, playing a role in subsequent platelet aggregation and clot stabilization. Genetic defects in GP1BA can lead to bleeding disorders such as Bernard-Soulier syndrome, highlighting the gene's critical role in normal hemostatic function.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY38. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone HIb-6"
- CAT
- Product Name
See other products for "GPIb"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0053-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-1) | WB | Human IgG |
| HPAB-S0054-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-2) | WB | Human IgG |
| HPAB-S0055-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-3) | WB | Human IgG |
| HPAB-S0056-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-5) | WB | Human IgG |
| HPAB-S0057-YC | Human Anti-GPIb Recombinant Antibody (clone HIb-6) | WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0053-YC-F(E) | Human Anti-GPIb Recombinant Antibody (clone HIb-1); Fab Fragment | WB | Human Fab |
| HPAB-S0054-YC-F(E) | Human Anti-GPIb Recombinant Antibody (clone HIb-2); Fab Fragment | WB | Human Fab |
| HPAB-S0055-YC-F(E) | Human Anti-GPIb Recombinant Antibody (clone HIb-3); Fab Fragment | WB | Human Fab |
| HPAB-S0056-YC-F(E) | Human Anti-GPIb Recombinant Antibody (clone HIb-5); Fab Fragment | WB | Human Fab |
| HPAB-S0057-YC-F(E) | Human Anti-GPIb Recombinant Antibody (clone HIb-6); Fab Fragment | WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0053-YC-S(P) | Human Anti-GPIb Recombinant Antibody (clone HIb-1); scFv Fragment | WB | Human scFv |
| HPAB-S0054-YC-S(P) | Human Anti-GPIb Recombinant Antibody (clone HIb-2); scFv Fragment | WB | Human scFv |
| HPAB-S0055-YC-S(P) | Human Anti-GPIb Recombinant Antibody (clone HIb-3); scFv Fragment | WB | Human scFv |
| HPAB-S0056-YC-S(P) | Human Anti-GPIb Recombinant Antibody (clone HIb-5); scFv Fragment | WB | Human scFv |
| HPAB-1619WJ-S(P) | Mouse Anti-GPIb Recombinant Antibody; scFv Fragment (clone 6B4) | ELISA, WB | Mouse scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Block, Cyt, FuncS, Inhib
Application: ELISA, WB, FC
Application: ELISA, FC, Neut, Inhib
-3.jpg)
Application: ELISA, WB
Application: ELISA, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
