Human Anti-HLA-DR (clone I-2) scFv-Fc Chimera
CAT#: VS-0425-FY116
This fusion protein targets HLA-DR, a major histocompatibility complex class II molecule involved in antigen presentation and immune response regulation. By binding to HLA-DR, it can modulate immune responses and has potential applications in autoimmune and transplant-related diseases.
Specifications
- Immunogen
- Purified HLA-DR molecules or cells expressing HLA-DR.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human HLA-DR
- Species Reactivity
- Human
- Clone
- I-2
- Applications
- Immunoassay
- Related Disease
- Autoimmune or inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- HLA-DR; Human Leukocyte Antigen-DR isotype
- Long Name
- Human Leukocyte Antigen-DR isotype
- Function
- The HLA-DR genes encode for HLA-DR, a major histocompatibility complex (MHC) class II cell surface receptor. As a key component of the adaptive immune system, HLA-DR's primary function is antigen presentation to CD4+ T helper cells.
Found predominantly on professional antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells, HLA-DR molecules bind to peptide fragments derived from extracellular pathogens. These peptide-HLA-DR complexes are then displayed on the APC surface, where they can be recognized by specific T cell receptors on CD4+ T cells. This interaction is crucial for activating T helper cells, which subsequently orchestrate various immune responses, including B cell activation and the recruitment of other immune cells to eliminate the threat. HLA-DR plays a central role in initiating and regulating antigen-specific immunity.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
- Product Name
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