Human Anti-HLA-DR (clone I-2) scFv-Fc Chimera
CAT#: VS-0425-FY116
This fusion protein targets HLA-DR, a major histocompatibility complex class II molecule involved in antigen presentation and immune response regulation. By binding to HLA-DR, it can modulate immune responses and has potential applications in autoimmune and transplant-related diseases.
Specifications
- Immunogen
- Purified HLA-DR molecules or cells expressing HLA-DR.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human HLA-DR
- Species Reactivity
- Human
- Clone
- I-2
- Applications
- Immunoassay
- Related Disease
- Autoimmune or inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- HLA-DR; Human Leukocyte Antigen-DR isotype
- Long Name
- Human Leukocyte Antigen-DR isotype
- Function
- The HLA-DR genes encode for HLA-DR, a major histocompatibility complex (MHC) class II cell surface receptor. As a key component of the adaptive immune system, HLA-DR's primary function is antigen presentation to CD4+ T helper cells.
Found predominantly on professional antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells, HLA-DR molecules bind to peptide fragments derived from extracellular pathogens. These peptide-HLA-DR complexes are then displayed on the APC surface, where they can be recognized by specific T cell receptors on CD4+ T cells. This interaction is crucial for activating T helper cells, which subsequently orchestrate various immune responses, including B cell activation and the recruitment of other immune cells to eliminate the threat. HLA-DR plays a central role in initiating and regulating antigen-specific immunity.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone I-2"
- CAT
- Product Name
See other products for "HLA-DR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-503 | Recombinant Anti-human HLA-DR Antibody | WB, IHC, FuncS | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-503-F(E) | Recombinant Anti-human HLA-DR Antibody Fab Fragment | RIA, IF, FuncS | Fab |
| HPAB-0210-WJ-F(E) | Human Anti-HLA-DR Recombinant Antibody (clone DR4B117); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-1155WJ-F(E) | Human Anti-HLA-DR Recombinant Antibody (clone HD4); Fab Fragment | ELISA | Human Fab |
| HPAB-1156WJ-F(E) | Human Anti-HLA-DR Recombinant Antibody (clone HD8); Fab Fragment | ELISA | Human Fab |
| HPAB-1206WJ-F(E) | Mouse Anti-HLA-DR Recombinant Antibody; Fab Fragment (HPAB-1206WJ-F(E)) | WB, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-503-S(P) | Recombinant Anti-human HLA-DR Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| HPAB-M0498-YC-S(P) | Mouse Anti-HLA-DR Recombinant Antibody; scFv Fragment (HPAB-M0498-YC-S(P)) | ELISA, FC, Cyt | Mouse scFv |
| HPAB-M0499-YC-S(P) | Mouse Anti-HLA-DR Recombinant Antibody; scFv Fragment (HPAB-M0499-YC-S(P)) | ELISA, FC, Cyt | Mouse scFv |
| HPAB-0210-WJ-S(P) | Human Anti-HLA-DR Recombinant Antibody (clone DR4B117); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-1542-FY-F(E) | Human Anti-HLA-DR Recombinant Antibody Fab Fragment (HPAB-1542-FY-F(E)) | WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-094CT | Anti-Human HLA-DR Recombinant Antibody ( L243) | FC, Inhib | |
| TAB-094CT-S(P) | Anti-Human HLA-DR Recombinant Antibody scFv Fragment ( L243) | ELISA, WB | |
| TAB-094CT-F(E) | Anti-Human HLA-DR Recombinant Antibody Fab Fragment ( L243) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-095CT | Anti-Human HLA-DR β Recombinant Antibody (1D09C3) | FC, Inhib, WB, IHC | Humanized antibody |
| TAB-095CT-S(P) | Anti-Human HLA-DR β Recombinant Antibody scFv Fragment (1D09C3) | ELISA | Humanized antibody |
| TAB-095CT-F(E) | Anti-Human HLA-DR β Recombinant Antibody Fab Fragment (1D09C3) | ELISA | Humanized antibody |
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