Human Anti-KIR2DL3 (clone 1-7F9) scFv-Fc Chimera
CAT#: VS-0425-FY141
The anti-KIR2DL3 scFv-FC is engineered to bind specifically to the KIR2DL3 receptor, which is crucial for immune regulation and interactions between natural killer (NK) cells and target cells. This fusion protein combines the antigen-binding capability of a single-chain variable fragment with the effector functions of an Fc domain, enhancing its therapeutic potential in modulating immune responses. It can be utilized in both research applications, such as studying NK cell biology, and potential therapeutic approaches to activate or inhibit NK cell activity in cancer treatment.
Specifications
- Immunogen
- The human monoclonal antibodies, including 1-7F9, were generated by immunizing transgenic mice engineered to express the human antibody repertoire with recombinant, soluble KIR protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The 1-7F9 clone produces a human monoclonal antibody that binds to KIR2DL1, KIR2DL2, and KIR2DL3.
- Species Reactivity
- Human
- Clone
- 1-7F9
- Applications
- ELISA, Western Blot, Flow Cytometry
- Related Disease
- Graft-Versus-Host Disease and Prostate Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The antibody at 10 μg/ml or 30 μg/ml in cytotoxicity assays.
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3; P58 Natural Killer Cell Receptor Clone CL-6; CD158 Antigen-Like Family Member B2; Killer Inhibitory Receptor Cl 2-3; P58 NK Receptor CL-6; KIR-023GB; CD158B2; KIRCL23; NKAT2A; NKAT2B; NKAT-2; NKAT2; Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 5; Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3; Killer Cell Immunoglobulin-Like Receptor Two Domains Long Cytoplasmic Tail 3; Natural Killer Cell Inhibitory Receptor KIR2DL3
- Gene ID
- 3804
- UniProt ID
- P43628
- Long Name
- Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3
- Sequence Similarities
- Belongs to the immunoglobulin superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn84, Asn178, and Asn211
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_056952.2
- Function
- Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7).
Inhibits the activity of NK cells thus preventing cell lysis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 1-7F9"
- CAT
- Product Name
See other products for "KIR2DL3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1790z | Mouse Anti-KIR2DL3 Recombinant Antibody (clone 13F10) | WB, ELISA, FC | Mouse IgG2a, κ |
| MOB-1180MZ | Recombinant Mouse Anti-Human KIR2DL3 Antibody (clone 200JJD422) | ELISA, FC, WB | Mouse antibody |
| HPAB-0263-CN | Mouse Anti-KIR2DL3 Recombinant Antibody (HPAB-0263-CN) | FC | Mouse IgG |
| FN-269CQ | Recombinant Mouse Anti-KIR2DL3 Antibody (DX27) | FC | Mouse IgG2a, κ |
| VS13-YC624 | Rabbit Anti-KIR2DL3 Recombinant Antibody (VS13-YC624) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0312MC | Recombinant Mouse Anti-KIR Antibody | ELISA, FACS, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1945 | Hi-Affi™ Recombinant Rabbit Anti-KIR2DL3 Monoclonal Antibody (DS1945AB) | FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0263-CN-S(P) | Mouse Anti-KIR2DL3 Recombinant Antibody; scFv Fragment (HPAB-0263-CN-S(P)) | FC | Mouse scFv |
| HPAB-0087-LSX-S(P) | Human Anti-KIR2DL3 Recombinant Antibody (clone 1-7F9); scFv Fragment | ELISA, WB, RIA | Human scFv |
| HPAB-0088-LSX-S(P) | Human Anti-KIR2DL3 Recombinant Antibody scFv Fragment (HPAB-0088-LSX-S(P)) | ELISA, WB, RIA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0263-CN-F(E) | Mouse Anti-KIR2DL3 Recombinant Antibody; Fab Fragment (HPAB-0263-CN-F(E)) | FC | Mouse Fab |
| HPAB-0087-LSX-F(E) | Human Anti-KIR2DL3 Recombinant Antibody (clone 1-7F9); Fab Fragment | ELISA, WB, RIA | Human Fab |
| HPAB-0088-LSX-F(E) | Human Anti-KIR2DL3 Recombinant Antibody Fab Fragment (HPAB-0088-LSX-F(E)) | ELISA, WB, RIA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC637 | Recombinant Anti-KIR2DL3 Vesicular Antibody, EV Displayed (VS-0425-YC637) | ELISA, FC, Neut, Cell-uptake |
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