Human Anti-KLK7 (clone B10) scFv-Fc Chimera
CAT#: VS-0125-FY1
The antibody is a scFv-Fc antibody targeting human tissue kallikrein-related peptidase 7 (KLK7). KLK7 is a serine protease involved in the physiological process of skin shedding. Dysregulated activity of KLK7 may lead to chronic conditions such as psoriasis, atopic dermatitis, and Netherton syndrome. Therefore, KLK7 has been identified as a potential therapeutic target. Its primary function is to regulate related skin physiological processes by inhibiting KLK7 activity, which may be utilized for the treatment of these skin disorders. This indicates that such antibodies hold promise as therapeutic agents against KLK7, potentially providing new strategies for treating skin abnormalities.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18994/1660_C7_3_selected.jpg
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- B10
- Applications
- Inhibition
- Related Disease
- Psoriasis, atopic dermatitis, and netherton syndrome
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This type of antibody holds potential as a therapeutic agent targeting KLK7, potentially offering a new strategy for the treatment of skin disorders.
Target
- Alternative Names
- Kallikrein Related Peptidase 7; Kallikrein 7 (Chymotryptic, Stratum Corneum); Stratum Corneum Chymotryptic Enzyme; Serine Protease 6; PRSS6; SCCE; HK7
- Gene ID
- 5650
- UniProt ID
- P49862
- Sequence Similarities
- Belongs to the peptidase S1 family. Kallikrein subfamily.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn246
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001193982.1; NP_001230055.1; NP_005037.1; NP_644806.1
- Function
- May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface.
Specific for amino acid residues with aromatic side chains in the P1 position.
Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'.
Could play a role in the activation of precursors to inflammatory cytokines.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "KLK7"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3031z | Mouse Anti-KLK7 Recombinant Antibody (clone 38C5) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| MOB-2163MZ | Recombinant Mouse Anti-Human KLK7 Antibody (clone NN0544-6K39) | Neut, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1651CQ | Recombinant Mouse Anti-KLK7 Antibody (CBL613) | WB, IP, Neut | IgG2a |
| NEUT-1652CQ | Recombinant Mouse Anti-KLK7 Antibody (MM0433-5J28) | WB, Neut | IgG1 |
| NEUT-1653CQ | Recombinant Mouse Anti-KLK7 Antibody (CBL131) | Neut, WB | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4295 | Hi-Affi™ Recombinant Rabbit Anti-KLK7 Monoclonal Antibody (SI381DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3809 | Anti-KLK7 Immunohistochemistry Kit | IHC |
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