Human Anti-KLK7 (clone B10) scFv-Fc Chimera (CAT#: VS-0125-FY1)
The antibody is a scFv-Fc antibody targeting human tissue kallikrein-related peptidase 7 (KLK7). KLK7 is a serine protease involved in the physiological process of skin shedding. Dysregulated activity of KLK7 may lead to chronic conditions such as psoriasis, atopic dermatitis, and Netherton syndrome. Therefore, KLK7 has been identified as a potential therapeutic target. Its primary function is to regulate related skin physiological processes by inhibiting KLK7 activity, which may be utilized for the treatment of these skin disorders. This indicates that such antibodies hold promise as therapeutic agents against KLK7, potentially providing new strategies for treating skin abnormalities.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18994/1660_C7_3_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18994/1660_C7_3_selected.jpg
Figure 2 Skin 1
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62126/145391_B_7_1_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62126/145391_B_7_1_selected.jpg
Figure 3 Skin
(Cells in corneal layer Staining: Medium Intensity: Moderate Quantity:>75% Cells in granular layer Staining: Medium Intensity: Moderate Quantity:>75% Hair follicles Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26342/59418_B_9_1.jpg
(Cells in corneal layer Staining: Medium Intensity: Moderate Quantity:>75% Cells in granular layer Staining: Medium Intensity: Moderate Quantity:>75% Hair follicles Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26342/59418_B_9_1.jpg
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169035-KLK7
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169035-KLK7
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- B10
- Applications
- Inhibition
- Related Disease
- Psoriasis, atopic dermatitis, and netherton syndrome
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This type of antibody holds potential as a therapeutic agent targeting KLK7, potentially offering a new strategy for the treatment of skin disorders.
Target
- Alternative Names
- Kallikrein Related Peptidase 7; Kallikrein 7 (Chymotryptic, Stratum Corneum); Stratum Corneum Chymotryptic Enzyme; Serine Protease 6; PRSS6; SCCE; HK7
- Gene ID
- 5650
- UniProt ID
- P49862
- Sequence Similarities
- Belongs to the peptidase S1 family. Kallikrein subfamily.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn246
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001193982.1; NP_001230055.1; NP_005037.1; NP_644806.1
- Function
- May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface.
Specific for amino acid residues with aromatic side chains in the P1 position.
Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'.
Could play a role in the activation of precursors to inflammatory cytokines.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "KLK7"
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IgG Antibody Products
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3031z | Mouse Anti-KLK7 Recombinant Antibody (clone 38C5) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| MOB-2163MZ | Recombinant Mouse Anti-Human KLK7 Antibody (clone NN0544-6K39) | Neut, WB | Mouse antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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