Human Anti-MASP2 scFv-Fc Chimera (VS-0425-FY150)
CAT#: VS-0425-FY150
Anti-MASP2 (mannan-binding lectin-associated serine protease 2) scFv-FC is a single-chain variable fragment (scFv) fused with an Fc region, designed for high specificity and affinity towards MASP2. This protein plays a crucial role in the complement activation pathway and is implicated in various pathological conditions. The scFv-FC format provides enhanced stability, longer half-life in circulation, and the ability to recruit immune effector functions, making it a potential therapeutic for diseases associated with complement dysregulation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29313/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows distinct plasma positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29313/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human skin
Immunohistochemical staining of human skin shows extracellular positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29314/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29313/72652_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29313/72652_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29313/72652_A_7_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29313/72652_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29313/72652_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000009724-MASP2
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MASP2
- Species Reactivity
- Human
- Applications
- Immunoassay
- Related Disease
- Masp2 Deficiency and Immunodeficiency Due To Masp-2 Deficiency
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Mannan Binding Lectin Serine Peptidase 2; Mannan-Binding Lectin Serine Peptidase 1 Pseudogene 1; Mannan-Binding Lectin Serine Protease 1 Pseudogene 1; Mannose-Binding Protein-Associated Serine Protease 2; Mannan-Binding Lectin Serine Protease 2; MBL-Associated Serine Protease 2; MASP-2; MBL-Associated Plasma Protein Of 19 KD
- Gene ID
- 10747
- UniProt ID
- O00187
- Long Name
- Mannan Binding Lectin Serine Peptidase 2
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Activated by cleavage after Arg-444.
The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation from GlyGen 1 site, 1 N-linked glycan (1 site)
- Protein Refseq
- XP_016855586.1; XP_047295714.1; XP_054189900.1; XP_054189901.1; NP_006601.2
- Function
- Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin.
After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1914z | Mouse Anti-MASP2 Recombinant Antibody (clone 30D10) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| MRO-0966-CN | Recombinant Mouse Anti-MASP2 Monoclonal Antibody (F3-4) | WB | Mouse IgG2b |
| MOB-0791-YJ | Rat Anti-MASP2 Recombinant Antibody (CBM85D) | IA, WB | Rat IgG1 |
| MOB-0807-YJ | Rat Anti-MASP2 Recombinant Antibody (CBM101D) | IA, WB | Rat IgG1 |
| VS-0723-WK7 | Human Anti-MASP2 Recombinant Antibody (clone Narsoplimab) | FC | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0722CL | Mouse Anti-MASP2 Recombinant Antibody (TAB-0722CL) | ELISA | Mouse IgG |
| TAB-0722CL-S(P) | Mouse Anti-MASP2 Recombinant Antibody; scFv Fragment (TAB-0722CL-S(P)) | ELISA | Mouse scFv |
| TAB-0722CL-F(E) | Mouse Anti-MASP2 Recombinant Antibody; Fab Fragment (TAB-0722CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0723CL | Human Anti-MASP2 Recombinant Antibody (TAB-0723CL) | ELISA | Chimeric antibody (mouse/human) |
| TAB-0723CL-S(P) | Mouse Anti-MASP2 Recombinant Antibody; scFv Fragment (TAB-0723CL-S(P)) | ELISA | Mouse scFv |
| TAB-0723CL-F(E) | Human Anti-MASP2 Recombinant Antibody; Fab Fragment (TAB-0723CL-F(E)) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0724CL | Human Anti-MASP2 Recombinant Antibody (TAB-0724CL) | ELISA | Human IgG |
| TAB-0724CL-S(P) | Human Anti-MASP2 Recombinant Antibody; scFv Fragment (TAB-0724CL-S(P)) | ELISA | Human scFv |
| TAB-0724CL-F(E) | Human Anti-MASP2 Recombinant Antibody; Fab Fragment (TAB-0724CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4267 | Anti-MASP2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC217 | Recombinant Anti-MASP2 Eliminating Antibody, pH-Sensitive (VS-0625-YC217) | Antigen-Sweeping In Vivo. | Mouse IgG |
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