Human Anti-MASP2 scFv-Fc Chimera (VS-0425-FY150) (CAT#: VS-0425-FY150)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human MASP2

• Species Reactivity
• Human

• Applications
• Immunoassay

• Related Disease
• Masp2 Deficiency and Immunodeficiency Due To Masp-2 Deficiency

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Mannan Binding Lectin Serine Peptidase 2; Mannan-Binding Lectin Serine Peptidase 1 Pseudogene 1; Mannan-Binding Lectin Serine Protease 1 Pseudogene 1; Mannose-Binding Protein-Associated Serine Protease 2; Mannan-Binding Lectin Serine Protease 2; MBL-Associated Serine Protease 2; MASP-2; MBL-Associated Plasma Protein Of 19 KD

• Gene ID
• 10747

• UniProt ID
• O00187

• Long Name
• Mannan Binding Lectin Serine Peptidase 2

• Sequence Similarities
• Belongs to the peptidase S1 family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  Activated by cleavage after Arg-444.
  The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt
  Glycosylation from GlyGen 1 site, 1 N-linked glycan (1 site)

• Protein Refseq
• XP_016855586.1; XP_047295714.1; XP_054189900.1; XP_054189901.1; NP_006601.2

• Function
• Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin.
  After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.

Select a product category from the dropdown menu below to view related products.