Human Anti-PILRA scFv-Fc Chimera (VS-0325-FY41) (CAT#: VS-0325-FY41)
The anti-PILRA scFv-Fc antibody targets Poliovirus Receptor-Related 1 (PILRA), a protein involved in immune responses and cell adhesion. It is designed to modulate PILRA function, which may have therapeutic implications in autoimmune and inflammatory diseases.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in both germinal and non-germinal center cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_6_8_selected.jpg
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in both germinal and non-germinal center cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_6_8_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_B_9_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_B_9_5.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_9_3.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_8_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_8_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_6_6.jpg
Figure 6 Appendix
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Lymphoid tissue Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_2_2.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Lymphoid tissue Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_2_2.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_8_8.jpg
(Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_8_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, HMC-1, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000085514-PILRA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000085514-PILRA
Specifications
- Immunogen
- Human PILRA protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human PILRA
- Species Reactivity
- Human, Cynomolgus, Mouse
- Applications
- Blocking, Flow Cytometry
- Related Disease
- Autoimmune and inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The hPA-002 antibody effectively inhibits PILRA Fc binding, with an IC₅₀ of approximately 0.75 nM.
Target
- Alternative Names
- Paired Immunoglobin Like Type 2 Receptor Alpha; Inhibitory Receptor PILR-Alpha; Cell Surface Receptor FDF03; Paired Immunoglobulin-Like Type 2 Receptor Alpha; Paired Immunoglobin-Like Type 2 Receptor Alpha; FDF03
- Gene ID
- 29992
- UniProt ID
- Q9UKJ1
- Long Name
- Paired Immunoglobin Like Type 2 Receptor Alpha
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- According to PubMed:10660620, N- and O-glycosylated.
According to PubMed:10903717, only N-glycosylated.
Phosphorylated on tyrosine residues.
Glycosylation at Asn100
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen
- Protein Refseq
- XP_047276247.1; XP_047276248.1; XP_054214012.1; XP_054214013.1; NP_038467.2
- Function
- PILRA (Paired Ig-like receptor A) is an inhibitory receptor expressed on various immune cells. It regulates immune responses by interacting with ligands such as CD99 and serves to dampen excessive immune activation.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0224-XY100 | Rabbit Anti-PILRA Recombinant Antibody (VS-0224-XY100) | ELISA, FC, Block | Rabbit IgG |
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