Human Anti-PILRA scFv-Fc Chimera (VS-0325-FY41)
CAT#: VS-0325-FY41
The anti-PILRA scFv-Fc antibody targets Poliovirus Receptor-Related 1 (PILRA), a protein involved in immune responses and cell adhesion. It is designed to modulate PILRA function, which may have therapeutic implications in autoimmune and inflammatory diseases.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows cytoplasmic positivity in both germinal and non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_6_8_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_6_6.jpg
Normal Tissue
Figure 6 Appendix
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Lymphoid tissue Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_2_2.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56132/159672_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, HMC-1, NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000085514-PILRA
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Specifications
- Immunogen
- Human PILRA protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human PILRA
- Species Reactivity
- Human, Cynomolgus, Mouse
- Applications
- Blocking, Flow Cytometry
- Related Disease
- Autoimmune and inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The hPA-002 antibody effectively inhibits PILRA Fc binding, with an IC₅₀ of approximately 0.75 nM.
Target
- Alternative Names
- Paired Immunoglobin Like Type 2 Receptor Alpha; Inhibitory Receptor PILR-Alpha; Cell Surface Receptor FDF03; Paired Immunoglobulin-Like Type 2 Receptor Alpha; Paired Immunoglobin-Like Type 2 Receptor Alpha; FDF03
- Gene ID
- 29992
- UniProt ID
- Q9UKJ1
- Long Name
- Paired Immunoglobin Like Type 2 Receptor Alpha
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- According to PubMed:10660620, N- and O-glycosylated.
According to PubMed:10903717, only N-glycosylated.
Phosphorylated on tyrosine residues.
Glycosylation at Asn100
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen
- Protein Refseq
- XP_047276247.1; XP_047276248.1; XP_054214012.1; XP_054214013.1; NP_038467.2
- Function
- PILRA (Paired Ig-like receptor A) is an inhibitory receptor expressed on various immune cells. It regulates immune responses by interacting with ligands such as CD99 and serves to dampen excessive immune activation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "PILRA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0224-XY100 | Rabbit Anti-PILRA Recombinant Antibody (VS-0224-XY100) | ELISA, FC, Block | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC52 | Recombinant Anti-PILRA Vesicular Antibody, EV Displayed (VS-0425-YC52) | Block, ELISA, FC, Cell-uptake |
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