ITGB3 Phosphorylation Antibody Panel (Total, pTyr 773, pTyr 785)
CAT#: VS-0725-YC53
The ITGB3 Phosphorylation Antibody Panel are sets of 3 antibodies, enabling the simultaneous detection of total ITGB3 alongside its key phosphorylation sites. Our comprehensive set includes antibodies against total ITGB3, as well as phosphorylated ITGB3 at pTyr 773 and pTyr 785. This panel streamlines your research into cell adhesion, platelet function, and angiogenesis, consistently delivering robust and reproducible results for your mechanistic investigations.
| Sub Cat | Component Name | Clone | Type | Target | Species Reactivity | Applications | |
| PABL-251 | Mouse Anti-ITGB3 Recombinant Antibody (clone 314.1) | 314.1 | Mouse IgG | ITGB3 | Human | WB, ELISA, IF, FuncS | |
| VS-0725-YC263 | Rabbit Anti-ITGB3 (pTyr 773) Polyclonal Antibody | Rabbit IgG | ITGB3 (pTyr 773) | Human, Mouse | IHC, WB | ||
| VS-0725-YC264 | Rabbit Anti-ITGB3 (pTyr 785) Polyclonal Antibody | Rabbit IgG | ITGB3 (pTyr 785) | Human, Mouse | WB |
More Infomation
Specifications
- Targets
- ITGB3 (Total, pTyr 773, pTyr 785)
- Species Reactivity
- Human
- Research Area
- ITGB3 Phosphorylation
- Introduction
- ITGB3, the gene encoding Integrin β3 (also known as CD61 or GPIIIa), is a crucial transmembrane adhesion receptor that plays vital roles in cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are heterodimeric proteins composed of an α and a β subunit. Integrin β3 partners predominantly with αIIb to form the αIIbβ3 integrin (found on platelets, essential for thrombosis and hemostasis) and with αV to form the αVβ3 integrin (found on various cell types including endothelial cells, involved in angiogenesis, cell migration, and tumor progression). The cytoplasmic tail of the β subunit is critical for transmitting signals from the extracellular environment into the cell (outside-in signaling) and for regulating the affinity of the integrin for its ligands (inside-out signaling). Tyrosine phosphorylation of the ITGB3 cytoplasmic tail is a key regulatory mechanism for both of these processes.
- Storage
- Store at 4°C for up to a week. For long-term storage, store at -20°C or below.
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