Quick™ MMAE (with VC-PAB linkage) Antibody Labeling Kit (VS-0824-FY221)
CAT#: VS-0824-FY221
Our antibody labeling kit allows for easy and efficient labeling of any IgG1 antibody with monomethyl auristatin E (MMAE) using a valine-citruline p-aminobenzylcarbamate (VC-PAB) linker. This kit is ideal for early stage screening of antibodies and includes maleimide-activated VC-PAB-MMAE, which can be directly coupled to the IgG1 after reduction through alkylation in a single step.
Simply follow the instructions provided in the kit to label your antibody with MMAE, allowing for targeted drug delivery and potential therapeutic applications. This kit is designed for researchers and scientists looking to enhance the efficacy of their antibody-based therapies.
Specifications
- Fluorescent Dye Name
- MMAE (with VC-PAB linkage)
- Application
- Antibody Labeling
- Composition
- 1) A microcentrifuge tube with 1.5 mL or less of hazardous MC-VC-PAB-MMAE solution weighing under 1 mg.
2) A microcentrifuge tube with 0.5 mL of non-hazardous Reagent A weighing less than 10 mg.
3) A tube containing either 1.5 or 6 mL of non-hazardous solution A.
4) A bottle with 4 or 12 mL of non-hazardous reducing buffer.
5) A bottle with 4 or 12 mL of non-hazardous labeling buffer.
6) A plastic bottle containing 20 or 60 mL of non-hazardous storage buffer (phosphate buffer saline).
7) A plastic bag containing non-hazardous centrifugal filter devices, desalting columns, and microcentrifuge tubes.
- Product Precautions
- This product is intended for research purposes only and is not intended for use in human, therapeutic, or diagnostic applications.
- Kit Storage
- Upon receiving the items, please store Box 1 in a freezer at -20°C or below and remove from the package. Store Box 2 in a refrigerator at 2-8°C.
- Assay Type
- Thiol Assay Kit with Purification
- Sample Type
- IgG1-type antibody
The total amount of protein should ideally be between 1-3 mg, as measured by UV, with a purity of greater than 90% determined by gel electrophoresis.
- Reactive Species
- The reactive species of the kit depends on the research application of the antibody.
- Fluorescent Dye Introduction
- Monomethyl auristatin E (MMAE) with MC-Val-Cit-PAB linkage is a potent cytotoxic agent that works by inhibiting cell division through blocking tubulin polymerization. The VC-PAB linker ensures stability in extracellular fluid, but is cleaved by cathepsin B once inside the tumor cell, activating the antimitotic mechanism. This compound possesses antioxidant, anti-inflammatory, anticancer, and insecticidal activities, making it a promising candidate for targeted cancer therapy.
- Alter Name
- Quick™ MMAE (with VC-PAB linkage) Antibody Labeling Kit; MMAE (with VC-PAB linkage) Antibody Labeling Kit
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