Quick™ MMAE (with VC-PAB linkage) Antibody Labeling Kit (VS-0824-FY221) (CAT#: VS-0824-FY221)

• Fluorescent Dye Name
• MMAE (with VC-PAB linkage)

• Application
• Antibody Labeling

• Composition
• 1) A microcentrifuge tube with 1.5 mL or less of hazardous MC-VC-PAB-MMAE solution weighing under 1 mg.
  2) A microcentrifuge tube with 0.5 mL of non-hazardous Reagent A weighing less than 10 mg.
  3) A tube containing either 1.5 or 6 mL of non-hazardous solution A.
  4) A bottle with 4 or 12 mL of non-hazardous reducing buffer.
  5) A bottle with 4 or 12 mL of non-hazardous labeling buffer.
  6) A plastic bottle containing 20 or 60 mL of non-hazardous storage buffer (phosphate buffer saline).
  7) A plastic bag containing non-hazardous centrifugal filter devices, desalting columns, and microcentrifuge tubes.

• Product Precautions
• This product is intended for research purposes only and is not intended for use in human, therapeutic, or diagnostic applications.

• Kit Storage
• Upon receiving the items, please store Box 1 in a freezer at -20°C or below and remove from the package. Store Box 2 in a refrigerator at 2-8°C.

• Assay Type
• Thiol Assay Kit with Purification

• Sample Type
• IgG1-type antibody
  The total amount of protein should ideally be between 1-3 mg, as measured by UV, with a purity of greater than 90% determined by gel electrophoresis.

• Reactive Species
• The reactive species of the kit depends on the research application of the antibody.

• Fluorescent Dye Introduction
• Monomethyl auristatin E (MMAE) with MC-Val-Cit-PAB linkage is a potent cytotoxic agent that works by inhibiting cell division through blocking tubulin polymerization. The VC-PAB linker ensures stability in extracellular fluid, but is cleaved by cathepsin B once inside the tumor cell, activating the antimitotic mechanism. This compound possesses antioxidant, anti-inflammatory, anticancer, and insecticidal activities, making it a promising candidate for targeted cancer therapy.

• Alter Name
• Quick™ MMAE (with VC-PAB linkage) Antibody Labeling Kit; MMAE (with VC-PAB linkage) Antibody Labeling Kit

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