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MMAE (with VC-PAB linkage)

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Anti-MMAE (with VC-PAB linkage) Products

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For Research Use Only. Not For Clinical Use.


Background

Monomethyl auristatin E (MMAE) with MC-Val-Cit-PAB linkage is a potent cytotoxic agent that works by inhibiting cell division through blocking tubulin polymerization. The VC-PAB linker ensures stability in extracellular fluid, but is cleaved by cathepsin B once inside the tumor cell, activating the antimitotic mechanism. This compound possesses antioxidant, anti-inflammatory, anticancer, and insecticidal activities, making it a promising candidate for targeted cancer therapy.
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