Mouse Anti-ENOX2 scFv-Fc Chimera (VS-0625-FY9)
CAT#: VS-0625-FY9
Anti-ENOX2 scFv-FC is a recombinant fusion protein designed to specifically target the Ecto-NOX Disulfide-Thiol Exchanger 2 (ENOX2) protein, also known as tumor-associated NADH oxidase (tNOX). ENOX2 is a cell surface protein uniquely and ubiquitously expressed in cancer cells but largely absent in normal cells, making it an attractive therapeutic target. The development of this scFv aims to provide a highly sensitive and specific reagent for cancer detection and diagnosis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1907_G4_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human smooth muscle
Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_5_7_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1913_A8_2_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1899_C11_6_cr5ba1f54fd5ccb_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_9_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_A_8_3.jpg
Normal Tissue
Figure 7 Smooth muscle
Smooth muscle cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_5_7.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165675-ENOX2
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human ENOX2
- Species Reactivity
- Human
- Applications
- Western Blot
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Ecto-NOX Disulfide-Thiol Exchanger 2; Cytosolic Ovarian Carcinoma Antigen 1; Ecto-NADPH Oxidase Disulfide-Thiol Exchanger 2; Tumor-Associated Hydroquinone Oxidase; Tumor-Associated NADH Oxidase; APK1 Antigen; COVA1; TNOX; APK1
- Gene ID
- 10495
- UniProt ID
- Q16206
- Long Name
- Ecto-NOX Disulfide-Thiol Exchanger 2
- Sequence Similarities
- Belongs to the ENOX family.
- Cellular Localization
- Cell membrane
Secreted, extracellular space
- Post Translation Modifications
- Glycosylated.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011529547.1; XP_011529551.1; XP_047297722.1; XP_047297723.1; XP_047297724.1
- Function
- May be involved in cell growth.
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface.
Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement.
The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ENOX2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-319 | Recombinant Anti-human ENOX2 Antibody | ELISA, IF, FuncS | IgG |
| MHH-319 | Recombinant Human Anti-human ENOX2 Antibody | ELISA, WB, FC, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-319-F(E) | Recombinant Anti-human ENOX2 Antibody Fab Fragment | IP, Neut, FuncS | Fab |
| MHH-319-F(E) | Recombinant Human Anti-human ENOX2 Antibody Fab Fragment | IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-319-S(P) | Recombinant Anti-human ENOX2 Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| MHH-319-S(P) | Recombinant Human Anti-human ENOX2 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
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