Mouse Anti-ENOX2 scFv-Fc Chimera (VS-0625-FY9) (CAT#: VS-0625-FY9)
Anti-ENOX2 scFv-FC is a recombinant fusion protein designed to specifically target the Ecto-NOX Disulfide-Thiol Exchanger 2 (ENOX2) protein, also known as tumor-associated NADH oxidase (tNOX). ENOX2 is a cell surface protein uniquely and ubiquitously expressed in cancer cells but largely absent in normal cells, making it an attractive therapeutic target. The development of this scFv aims to provide a highly sensitive and specific reagent for cancer detection and diagnosis.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1907_G4_3_selected.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1907_G4_3_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1913_A8_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1913_A8_2_blue_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1899_C11_6_cr5ba1f54fd5ccb_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3027/1899_C11_6_cr5ba1f54fd5ccb_blue_red_green.jpg
Figure 2 IHC staining of human smooth muscle
(Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_5_7_selected.jpg
(Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_5_7_selected.jpg
Figure 5 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_9_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_9_5.jpg
Figure 6 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_A_8_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_A_8_3.jpg
Figure 7 Smooth muscle
(Smooth muscle cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_5_7.jpg
(Smooth muscle cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/514/985_B_5_7.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165675-ENOX2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165675-ENOX2
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human ENOX2
- Species Reactivity
- Human
- Applications
- Western Blot
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Ecto-NOX Disulfide-Thiol Exchanger 2; Cytosolic Ovarian Carcinoma Antigen 1; Ecto-NADPH Oxidase Disulfide-Thiol Exchanger 2; Tumor-Associated Hydroquinone Oxidase; Tumor-Associated NADH Oxidase; APK1 Antigen; COVA1; TNOX; APK1
- Gene ID
- 10495
- UniProt ID
- Q16206
- Long Name
- Ecto-NOX Disulfide-Thiol Exchanger 2
- Sequence Similarities
- Belongs to the ENOX family.
- Cellular Localization
- Cell membrane
Secreted, extracellular space
- Post Translation Modifications
- Glycosylated.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011529547.1; XP_011529551.1; XP_047297722.1; XP_047297723.1; XP_047297724.1
- Function
- May be involved in cell growth.
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface.
Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement.
The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-319 | Recombinant Anti-human ENOX2 Antibody | ELISA, IF, FuncS | IgG |
| MHH-319 | Recombinant Human Anti-human ENOX2 Antibody | ELISA, WB, FC, FuncS | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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