Mouse Anti-IFITM3 scFv-Fc Chimera (VS-0325-FY207)
CAT#: VS-0325-FY207
The anti-IFITM3 scFv-Fc antibody targets IFITM3, a protein involved in antiviral responses and cellular membrane dynamics. This antibody is designed to provide researchers with a tool to study the role of IFITM3 in viral infections and immune responses. The scFv-Fc format ensures high specificity and prolonged activity, making it ideal for investigating IFITM3's function in cell signaling and viral entry mechanisms.
Gene Expression
Normal Tissue
Figure 1 Testis
Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4337/13614_A_5_6.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4337/13614_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4337/13614_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4337/13614_A_8_5.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4337/13614_B_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HHSteC, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000142089-IFITM3
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Specifications
- Immunogen
- Chicken IFITM3 protein
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Chicken IFITM3 protein
- Species Reactivity
- Chicken
- Applications
- Western Blot, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interferon Induced Transmembrane Protein 3
- Gene ID
- 10410
- UniProt ID
- Q01628
- Long Name
- Interferon Induced Transmembrane Protein 3
- Sequence Similarities
- Belongs to the CD225/Dispanin family.
- Cellular Localization
- Cell membrane; Late endosome membrane; Early endosome membrane; Lysosome membrane; Cytoplasm, perinuclear region
- Post Translation Modifications
- Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus and hepatitis C virus (HCV).
Has no effect on anti-SARS-CoV-2 activity.
Not glycosylated.
Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages.
Ubiquitination negatively regulates antiviral activity.
Lys-24 is the most prevalent ubiquitination site.
Phosphorylation at Tyr-20 is required for endosomal and lysosomal location.
Ubiquitination at Lys24, Lys83, Lys88, and Lys104
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_066362.2
- Function
- Chicken IFITM3 (Interferon-induced transmembrane protein 3) is an antiviral protein that inhibits viral entry into host cells. It plays a role in the innate immune response to influenza and other viruses in chickens.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "IFITM3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2715z | Mouse Anti-IFITM3 Recombinant Antibody (clone 43A6) | WB, ELISA, FC, IF, IHC | Mouse IgG1 |
| MOB-0745CT | Recombinant Mouse anti-Human IFITM3 Monoclonal antibody (EML1073) | WB | |
| MRO-0608-CN | Rabbit Anti-IFITM3 Recombinant Antibody (clone JU73-02) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK845 | Mouse Anti-IFITM3 Recombinant Antibody (VS3-WK845) | WB | Mouse IgG |
| VS3-FY726 | Recombinant Rabbit Anti-IFITM3 Antibody (clone R09-6I5) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1739 | Rabbit Anti-IFITM3 Recombinant Antibody (clone DS1739AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3402 | Anti-IFITM3 Immunohistochemistry Kit | IHC |
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