Mouse Anti-IFITM3 scFv-Fc Chimera (VS-0325-FY207) (CAT#: VS-0325-FY207)

• Immunogen
• Chicken IFITM3 protein

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• Chicken IFITM3 protein

• Species Reactivity
• Chicken

• Applications
• Western Blot, ELISA

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Interferon Induced Transmembrane Protein 3

• Gene ID
• 10410

• UniProt ID
• Q01628

• Long Name
• Interferon Induced Transmembrane Protein 3

• Sequence Similarities
• Belongs to the CD225/Dispanin family.

• Cellular Localization
• Cell membrane; Late endosome membrane; Early endosome membrane; Lysosome membrane; Cytoplasm, perinuclear region

• Post Translation Modifications
• Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus and hepatitis C virus (HCV).
  Has no effect on anti-SARS-CoV-2 activity.
  Not glycosylated.
  Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages.
  Ubiquitination negatively regulates antiviral activity.
  Lys-24 is the most prevalent ubiquitination site.
  Phosphorylation at Tyr-20 is required for endosomal and lysosomal location.
  Ubiquitination at Lys24, Lys83, Lys88, and Lys104
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_066362.2

• Function
• Chicken IFITM3 (Interferon-induced transmembrane protein 3) is an antiviral protein that inhibits viral entry into host cells. It plays a role in the innate immune response to influenza and other viruses in chickens.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

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