Mouse Anti-SERINC5 (clone 4D4.8) scFv-Fc Chimera
CAT#: VS-0425-FY27
The anti-SERINC5 scFv-Fc antibody is a monoclonal antibody specifically designed to bind to the human SERINC5 protein. SERINC5 is a transmembrane protein involved in the regulation of lipid transport between the intracellular and extracellular environments. This antibody specifically binds to SERINC5 through its single-chain variable fragment (scFv) domain, while the Fc fragment endows it with the ability to interact with immune effector molecules such as Fc receptors and the complement system.
Specifications
- Immunogen
- KLH Conjugate Human SERINC5 Peptide: GGEDTEEQQPGKEG.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human SERINC5
- Species Reactivity
- Human
- Clone
- 4D4.8
- Applications
- Flow Cytometry, ELISA, Western Blot
- Related Disease
- Branchiootic Syndrome
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Serine Incorporator 5; C5orf12; Chromosome 5 Open Reading Frame 12; TPO1
- Gene ID
- 256987
- UniProt ID
- Q86VE9
- Long Name
- Serine Incorporator 5
- Sequence Similarities
- Belongs to the TDE1 family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein; Cytoplasm, perinuclear region
- Post Translation Modifications
- Glycosylation at Asn113 and Asn183
Ubiquitination at Lys373
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- XP_011541606.1; XP_047273035.1; XP_047273036.1; XP_054208295.1; XP_054208296.1
- Function
- Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection.
Impairs the penetration of the viral particle into the cytoplasm.
Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine.
Functions as a scramblase that flips lipids in both directions across the membrane.
Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity.
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY27. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, Inhib, FC, ELISA
-5.jpg)
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FuncS
Application: ELISA, FC, IHC, Neut
-4.jpg)
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
