Mouse Anti-SERINC5 (clone 4D4.8) scFv-Fc Chimera (CAT#: VS-0425-FY27)
The anti-SERINC5 scFv-Fc antibody is a monoclonal antibody specifically designed to bind to the human SERINC5 protein. SERINC5 is a transmembrane protein involved in the regulation of lipid transport between the intracellular and extracellular environments. This antibody specifically binds to SERINC5 through its single-chain variable fragment (scFv) domain, while the Fc fragment endows it with the ability to interact with immune effector molecules such as Fc receptors and the complement system.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Specifications
- Immunogen
- KLH Conjugate Human SERINC5 Peptide: GGEDTEEQQPGKEG.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human SERINC5
- Species Reactivity
- Human
- Clone
- 4D4.8
- Applications
- Flow Cytometry, ELISA, Western Blot
- Related Disease
- Branchiootic Syndrome
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Serine Incorporator 5; C5orf12; Chromosome 5 Open Reading Frame 12; TPO1
- Gene ID
- 256987
- UniProt ID
- Q86VE9
- Long Name
- Serine Incorporator 5
- Sequence Similarities
- Belongs to the TDE1 family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein; Cytoplasm, perinuclear region
- Post Translation Modifications
- Glycosylation at Asn113 and Asn183
Ubiquitination at Lys373
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- XP_011541606.1; XP_047273035.1; XP_047273036.1; XP_054208295.1; XP_054208296.1
- Function
- Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection.
Impairs the penetration of the viral particle into the cytoplasm.
Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine.
Functions as a scramblase that flips lipids in both directions across the membrane.
Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity.
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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