Recombinant Anti-ABCA1 Vesicular Antibody, EV Displayed (VS-0425-YC321)
CAT#: VS-0425-YC321
The Recombinant Anti-ABCA1 Vesicular Antibody, EV Displayed (VS-0425-YC321) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ABCA1-expressed cells or tissues. The ABCA1 is an ABC transporter that is crucial for lipid transport, with mutations linked to Tangier's disease, supporting cholesterol efflux.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57283/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69889/151525_B_7_5.jpg
Normal Tissue
Figure 3 Lung
Macrophages Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69889/151525_A_1_4.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69889/151525_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69889/151525_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69889/151525_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69889/151525_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69889/151525_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HSkMC, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165029-ABCA1
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ABCA1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ATP binding cassette subfamily A member 1
- Biological Process
- Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport
- Molecular Function
- Translocase
- Cellular Localization
- Plasma membrane, Golgi apparatus
- Introduction
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
- Alternative Names
- ABC1, HDLDT1, TGD
- Gene ID
- 19
- UniProt ID
- O95477
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ABCA1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4000z | Mouse Anti-ABCA1 Recombinant Antibody (clone 40C6) | WB, FC, ICC, IF, IHC | Mouse IgG2b, κ |
| MRO-1624-CN | Rabbit Anti-ABCA1 Polyclonal Antibody (MRO-1624-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-XY1 | Mouse Anti-ABCA1 Recombinant Antibody (clone 4G2) | WB, IP, IF, IHC | Mouse IgG1 |
| VS7-HM8 | Mouse Anti-ABCA1 Recombinant Antibody (clone 6B7A11) | ICC, FCM | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0008 | Hi-Affi™ Rabbit Anti-ABCA1 Recombinant Antibody (clone DS8AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY11 | Anti-ABCA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY12 | Anti-Mouse ABCA1 Immunohistochemistry Kit | IHC |
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