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ABCA1
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- Rabbit Anti-ABCA1 Polyclonal Antibody (MRO-1624-CN) (MRO-1624-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Mouse Anti-ABCA1 Antibody, mRNA (TAB-003CL-mRNA)
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- Species Reactivity: Human
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, FC, ICC, IF, IHC
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- Anti-Human ABCA1 Recombinant Antibody (TAB-003CL)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Antibody
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- Anti-Human ABCA1 Recombinant Antibody Fab Fragment (ABCA1-3/84) (TAB-0630CLV-F(E))
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- Anti-Human ABCA1 Recombinant Antibody Fab Fragment (ABCA1-3/125) (TAB-0631CLV-F(E))
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- Anti-Human ABCA1 Recombinant Antibody Fab Fragment (ABCA1-4/18) (TAB-0632CLV-F(E))
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- Anti-Human ABCA1 Recombinant Antibody scFv Fragment (ABCA1-3/84) (TAB-0630CLV-S(P))
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- Anti-Human ABCA1 Recombinant Antibody scFv Fragment (ABCA1-3/125) (TAB-0631CLV-S(P))
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- Anti-Human ABCA1 Recombinant Antibody scFv Fragment (ABCA1-4/18) (TAB-0632CLV-S(P))
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- Anti-Human ABCA1 Recombinant Antibody (ABCA1-3/84) (TAB-0630CLV)
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- Anti-Human ABCA1 Recombinant Antibody (ABCA1-3/125) (TAB-0631CLV)
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- Anti-Human ABCA1 Recombinant Antibody (ABCA1-4/18) (TAB-0632CLV)
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- Anti-ABCA1 Immunohistochemistry Kit (VS-0525-XY11)
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- Species Reactivity: Human
- Target: ABCA1
- Application: IHC
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- Anti-Mouse ABCA1 Immunohistochemistry Kit (VS-0525-XY12)
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- Species Reactivity: Human, Mouse, Rat
- Target: ABCA1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatocytes, Kupffer cells, Langerhans cells, Alveolar cells type 1)
Immune cell specificity
Group enriched (eosinophil, neutrophil)
Cell line specificity
Cell line enhanced (HSkMC, U-87 MG)
Interaction
Interacts with MEGF10 (PubMed:17205124). May interact with APOE1; functionally associated with APOE1 in the biogenesis of HDLs (PubMed:14754908). Interacts with ABCA8; this interaction potentiates cholesterol efflux (PubMed:28882873). Interacts with ABCA12 and NR1H2; this interaction is required for ABCA1 localization to the cell surface and is necessary for its normal activity and stability (PubMed:23931754).
Molecular function
Translocase
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