Recombinant Anti-ABCA4 Vesicular Antibody, EV Displayed (VS-0425-YC735)
CAT#: VS-0425-YC735
The Recombinant Anti-ABCA4 Vesicular Antibody, EV Displayed (VS-0425-YC735) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ABCA4-expressed cells or tissues. ABCA4 is a retina-specific ABC transporter, essential for transporting molecules and associated with retinal diseases like Stargardt disease and retinitis pigmentosa.
Gene Expression
Normal Tissue
Figure 1 Low expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78826/167673_A_3_3_val_selected.jpg
Normal Tissue
Figure 2 Kidney
Collecting ducts Staining: High Intensity: Strong Quantity: 75%-25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25% Proximal tubules
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78826/167673_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78826/167673_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (BEWO, EFO-21, HeLa, SK-BR-3, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198691-ABCA4
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ABCA4
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse, Bovine, Xenopus laevis, Xenopus tropicalis
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ATP binding cassette subfamily A member 4
- Biological Process
- Sensory transduction, Transport, Vision
- Molecular Function
- Translocase
- Cellular Localization
- Endoplasmic reticulum
- Introduction
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.
- Alternative Names
- ABCR, ARMD2, CORD3, FFM, RP19, STGD, STGD1
- Gene ID
- 24
- UniProt ID
- P78363
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Datasheet
MSDS
COA
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See other products for "ABCA4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1014CQ | Mouse Anti-ABCA4 Recombinant Antibody (clone Rim 3F4) | IP, WB, ELISA, IF, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY13 | Anti-Mouse ABCA4 Immunohistochemistry Kit | IHC |
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