Recombinant Anti-ABCA4 Vesicular Antibody, EV Displayed (VS-0425-YC735) (CAT#: VS-0425-YC735)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• ABCA4

• Host Animal
• Mouse

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Mouse, Bovine, Xenopus laevis, Xenopus tropicalis

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• ATP binding cassette subfamily A member 4

• Biological Process
• Sensory transduction, Transport, Vision

• Molecular Function
• Translocase

• Cellular Localization
• Endoplasmic reticulum

• Introduction
• The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

• Alternative Names
• ABCR, ARMD2, CORD3, FFM, RP19, STGD, STGD1

• Gene ID
• 24

• UniProt ID
• P78363

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