Recombinant Anti-ACE Vesicular Antibody, EV Displayed (VS-0425-YC319)
CAT#: VS-0425-YC319
The Recombinant Anti-ACE Vesicular Antibody, EV Displayed (VS-0425-YC319) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ACE-expressed cells or tissues. The ACE is an enzyme catalyzing angiotensin conversion, essential for blood pressure regulation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line ASC TERT1
Immunofluorescent staining of human cell line ASC TERT1 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69790/1774_D3_18_cr5950fc2aec9fc_selected.jpg
Normal Tissue
Figure 2 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29298/100430_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29298/100430_A_6_6.jpg
Normal Tissue
Figure 4 Seminal vesicle
Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29298/100430_A_9_6.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (ASC TERT1, HUVEC TERT2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000159640-ACE
❮
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ACE
- Host Animal
- Human
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Angiotensin I converting enzyme
- Molecular Function
- Calmodulin-binding, Carboxypeptidase, Hydrolase, Metalloprotease, Protease
- Cellular Localization
- Vesicles
- Introduction
- This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.
- Alternative Names
- ACE1, CD143, DCP1
- Gene ID
- 1636
- UniProt ID
- P12821
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ACE"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-29 | Recombinant Anti-human ACE Antibody | ELISA, IF, FuncS | IgG |
| MHH-29 | Recombinant Human Anti-human ACE Antibody | WB, Neut, FuncS | IgG |
| MRO-0020-CN | Rabbit Anti-ACE Recombinant Antibody (clone JM59-32) | WB, IHC, FC | Rabbit IgG |
| VS4-WK5 | Mouse Anti-ACE Recombinant Antibody (VS4-WK5) | ELISA, WB | Mouse IgG1 |
| VS7-HM15 | Mouse Anti-ACE Recombinant Antibody (clone CBL009HM) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-29-F(E) | Recombinant Anti-human ACE Antibody Fab Fragment | RIA, IP, FuncS | Fab |
| MHH-29-F(E) | Recombinant Human Anti-human ACE Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-29-S(P) | Recombinant Anti-human ACE Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-29-S(P) | Recombinant Human Anti-human ACE Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0635CLV | Anti-Human ACE Recombinant Antibody (9B9) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0035 | Hi-Affi™ Rabbit Anti-ACE Recombinant Antibody (clone DS35AB) | WB, FC, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY1 | CytoStream™ Mouse Anti-ACE Recombinant Antibody (VS-0225-XY1) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY70 | Anti-ACE Immunohistochemistry Kit | IHC | |
| VS-0525-XY71 | Anti-Mouse ACE Immunohistochemistry Kit | IHC |
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