Anti-Human ACE Recombinant Antibody (9B9)
CAT#: TAB-0635CLV
The anti-ACE antibody 9B9 specifically binds to angiotensin-converting enzyme, which is an important regulator of blood pressure, and is expressed in epithelial cell, luminal surface of endothelial cell. 9B9 can be used for treating the lung malady.
Published Data
Gene Expression
ELISA
Figure 1 mAb-induced ACE shedding.
CHO-ACE cells were incubated with different anti-ACE mAbs (10 µg/ml) at 4 °C in a binding assay (A, cell ELISA) and at 37 °C in an assay of ACE release (B) for 4 h. (C) The ratio of shedding to binding for each mAb.
Balyasnikova, I. V., Karran, E. H., Albrecht, R. F., & Danilov, S. M. (2002). Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface. Biochemical Journal, 362(3), 585-595.
ELISA
Figure 2 Effect of low temperature and 1,10-phenanthroline on basal and antibody-induced ACE shedding.
(A) CHO-ACE cells were incubated in the presence of mAbs to ACE (10 µg/ml) at 4 or 37 °C for 4 h (n¯3). (B) CHO-ACE cells were pre-incubated with 1,10-phenanthroline (5 mM) during 30 min at 37 °C, after which mAbs to ACE (10 µg/ml) were added for the subsequent 4 h. ACE release was estimated by measuring ACE activity in the culture fluid (n¯3). (C) The mAb binding in the presence of 1,10-phenanthroline was estimated by cell ELISA, as described in the Materials and methods section (n¯3). mIgG, non-immune mouse IgG.
Balyasnikova, I. V., Karran, E. H., Albrecht, R. F., & Danilov, S. M. (2002). Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface. Biochemical Journal, 362(3), 585-595.
❮
❯
Subcellular Location
Figure 1 IF staining of human cell line ASC TERT1
Immunofluorescent staining of human cell line ASC TERT1 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69790/1774_D3_18_cr5950fc2aec9fc_selected.jpg
Normal Tissue
Figure 2 Kidney
Proximal tubules (microvilli)
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29298/100430_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29298/100430_A_6_6.jpg
Normal Tissue
Figure 4 Seminal vesicle
Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29298/100430_A_9_6.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (ASC TERT1, HUVEC TERT2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000159640-ACE
❮
❯
Specifications
- Host Species
- Human
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Clone
- 9B9
- Applications
- ELISA
- Related Disease
- Lung malady
Applications
- Application Notes
- The ACE antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for TAB-0635CLV. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 9B9"
- CAT
- Product Name
See other products for "ACE"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-29-F(E) | Recombinant Anti-human ACE Antibody Fab Fragment | RIA, IP, FuncS | Fab |
| MHH-29-F(E) | Recombinant Human Anti-human ACE Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-29-S(P) | Recombinant Anti-human ACE Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-29-S(P) | Recombinant Human Anti-human ACE Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-29 | Recombinant Human Anti-human ACE Antibody | WB, Neut, FuncS | IgG |
| ZG-0259F | Mouse Anti-ACE Recombinant Antibody (ZG-0259F) | WB | Mouse IgG |
| ZG-0287F | Mouse Anti-ACE Recombinant Antibody (ZG-0287F) | WB | Mouse IgG |
| ZG-0525J | Rabbit Anti-ACE Recombinant Antibody (clone 2H8) | ELISA, IHC | Rabbit IgG |
| VS13-YC13 | Rabbit Anti-Ace Recombinant Antibody (VS13-YC13) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0035 | Hi-Affi™ Rabbit Anti-ACE Recombinant Antibody (clone DS35AB) | WB, FC, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY1 | CytoStream™ Mouse Anti-ACE Recombinant Antibody (VS-0225-XY1) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC319 | Recombinant Anti-ACE Vesicular Antibody, EV Displayed (VS-0425-YC319) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY70 | Anti-ACE Immunohistochemistry Kit | IHC | |
| VS-0525-XY71 | Anti-Mouse ACE Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
-3-1.png)
Application: ELISA, Inhib, FC
Application: WB, ELISA, FC, IHC, IP
Application: Neut, FC
Application: ELISA, IHC, FC, IP, IF, BL
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
