Anti-Human ACE Recombinant Antibody (9B9) (CAT#: TAB-0635CLV)
The anti-ACE antibody 9B9 specifically binds to angiotensin-converting enzyme, which is an important regulator of blood pressure, and is expressed in epithelial cell, luminal surface of endothelial cell. 9B9 can be used for treating the lung malady.
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ELISA
Figure 1 mAb-induced ACE shedding.
CHO-ACE cells were incubated with different anti-ACE mAbs (10 µg/ml) at 4 °C in a binding assay (A, cell ELISA) and at 37 °C in an assay of ACE release (B) for 4 h. (C) The ratio of shedding to binding for each mAb.
Balyasnikova, I. V., Karran, E. H., Albrecht, R. F., & Danilov, S. M. (2002). Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface. Biochemical Journal, 362(3), 585-595.
ELISA
Figure 2 Effect of low temperature and 1,10-phenanthroline on basal and antibody-induced ACE shedding.
(A) CHO-ACE cells were incubated in the presence of mAbs to ACE (10 µg/ml) at 4 or 37 °C for 4 h (n¯3). (B) CHO-ACE cells were pre-incubated with 1,10-phenanthroline (5 mM) during 30 min at 37 °C, after which mAbs to ACE (10 µg/ml) were added for the subsequent 4 h. ACE release was estimated by measuring ACE activity in the culture fluid (n¯3). (C) The mAb binding in the presence of 1,10-phenanthroline was estimated by cell ELISA, as described in the Materials and methods section (n¯3). mIgG, non-immune mouse IgG.
Balyasnikova, I. V., Karran, E. H., Albrecht, R. F., & Danilov, S. M. (2002). Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface. Biochemical Journal, 362(3), 585-595.
Specifications
- Host Species
- Human
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Clone
- 9B9
- Applications
- ELISA
- Related Disease
- Lung malady
Applications
- Application Notes
- The ACE antibody has been reported in applications of Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- ACE; angiotensin I converting enzyme; DCP; ICH; ACE1; DCP1; CD143; MVCD
- Gene ID
- 1636
- UniProt ID
- P12821
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-29-F(E) | Recombinant Anti-human ACE Antibody Fab Fragment | RIA, IP, FuncS | Fab |
| MHH-29-F(E) | Recombinant Human Anti-human ACE Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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