Recombinant Anti-ADAM12 Vesicular Antibody, EV Displayed (VS-0425-YC314)
CAT#: VS-0425-YC314
The Recombinant Anti-ADAM12 Vesicular Antibody, EV Displayed (VS-0425-YC314) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ADAM12-expressed cells or tissues. The ADAM12 is a protease involved in cell interactions and is implicated in processes like neurogenesis, with maternal serum expression linked to prenatal development.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30867/380_A6_3_selected.jpg
Normal Tissue
Figure 2 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30866/156493_A_6_6.jpg
Normal Tissue
Figure 3 High expression in placenta
Decidual cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30866/156493_A_2_7.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30866/156493_A_8_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148848-ADAM12
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ADAM12
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ADAM metallopeptidase domain 12
- Biological Process
- Cell adhesion
- Molecular Function
- Hydrolase, Metalloprotease, Protease
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
- Alternative Names
- MCMPMltna, MLTN
- Gene ID
- 8038
- UniProt ID
- O43184
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ADAM12"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0665CLV | Anti-Human ADAM12 Recombinant Antibody (7B8) | IF |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0435MZ | Mouse Anti-ADAM12 Recombinant Antibody (clone 632525) | WB | Mouse IgG1 |
| VS-0524-YC17 | Mouse Anti-ADAM12 Recombinant Antibody (clone F1196-113-1) | ELISA, Inhib, Antagonist | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3948 | Hi-Affi™ Rabbit Anti-ADAM12 Recombinant Antibody (clone SI8DS) | ELISA | Rabbit IgG |
| MOR-3949 | Hi-Affi™ Rabbit Anti-ADAM12 Recombinant Antibody (clone SI9DS) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC602 | AbPlus™ Anti-ADAM12 Magnetic Beads (VS-0724-YC602) | IP, Protein Purification |
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