Recombinant Anti-AGT Vesicular Antibody, EV Displayed (VS-0425-YC435)
CAT#: VS-0425-YC435
The Recombinant Anti-AGT Vesicular Antibody, EV Displayed (VS-0425-YC435) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to AGT-expressed cells or tissues. The AGT is angiotensinogen, playing roles in blood pressure regulation and linked to renal and cardiovascular conditions.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows distinct positivity in plasma, glandular cells were negative.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25798/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25798/151642_B_8_5.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25798/151642_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Proximal tubules (cell body) Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25798/151642_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (Hep G2, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000135744-AGT
❮
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- AGT
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Angiotensinogen
- Molecular Function
- Vasoactive, Vasoconstrictor
- Introduction
- The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
- Alternative Names
- SERPINA8
- Gene ID
- 183
- UniProt ID
- P01019
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Related Diseases
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "AGT"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1972z | Mouse Anti-AGT Recombinant Antibody (clone 32C7) | WB, ELISA, IHC | Mouse IgG2b |
| MRO-0097-CN | Rabbit Anti-AGT Recombinant Antibody (clone CBACN-031) | WB, IF, IP | Rabbit IgG |
| ZG-0266F | Mouse Anti-AGT Recombinant Antibody (ZG-0266F) | WB, ELISA | Mouse IgG |
| ZG-0534J | Rabbit Anti-AGT Recombinant Antibody (clone 8A9) | ELISA, IHC | Rabbit IgG |
| VS7-HM54 | Mouse Anti-AGT Recombinant Antibody (clone CBL020HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-008 | Mouse Anti-AGT Recombinant Antibody (clone mAb131); Fab Fragment | WB, IF, FuncS | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-008 | Mouse Anti-AGT Recombinant Antibody (clone mAb131); scFv Fragment | WB, IF, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0103 | Hi-Affi™ Rabbit Anti-AGT Recombinant Antibody (clone DS103AB) | FC, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC582 | AbPlus™ Anti-AGT Magnetic Beads (VS-0724-YC582) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY60 | Anti-AGT Immunohistochemistry Kit | IHC | |
| VS-0525-XY226 | Anti-Mouse AGT Immunohistochemistry Kit | IHC | |
| VS-0525-XY225 | Anti-Human AGT Immunohistochemistry Kit | IHC |
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