Recombinant Anti-ECSCR Vesicular Antibody, EV Displayed (VS-0425-YC187)
CAT#: VS-0425-YC187
The Recombinant Anti-ECSCR Vesicular Antibody, EV Displayed (VS-0425-YC187) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ECSCR-expressed cells or tissues. The ECSCR is a protein predominantly found in endothelial cells, playing a role in cell shape changes and EGF-induced cell migration. It enhances activation of vascular endothelial growth factor receptor-2/kind and may play a role in angiogenesis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63337/1769_A8_8_cr59e0801e38b23_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (EFO-21, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000249751-ECSCR
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ECSCR
- Host Animal
- Mouse
- Antibody Isotype
- IgG1
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein G
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Endothelial cell surface expressed chemotaxis and apoptosis regulator
- Biological Process
- Angiogenesis, Apoptosis, Chemotaxis, Differentiation
- Molecular Function
- Developmental protein
- Cellular Localization
- Vesicles, Plasma membrane, Nucleoplasm
- Introduction
- The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases.
- Alternative Names
- ARIA, ECSM2
- Gene ID
- 641700
- UniProt ID
- Q19T08
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Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ECSCR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3014z | Recombinant Anti-Human ECSCR Antibody | ELISA, IP, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3014z-F(E) | Recombinant Anti-Human ECSCR Antibody Fab Fragment | RIA, WB, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3014z-S(P) | Recombinant Anti-Human ECSCR Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
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