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ECSCR

The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants.
Predicted location

Membrane

Single cell type specificity

Group enriched (Adipocytes, Endothelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (EFO-21, HUVEC TERT2, TIME)

Interaction

Interacts with FLNA. Interacts with the 20S proteasome subunit PSMA7.

Molecular function

Developmental protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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