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    Recombinant Anti-EDNRA Vesicular Antibody, EV Displayed (VS-0425-YC465) (CAT#: VS-0425-YC465)

    The Recombinant Anti-EDNRA Vesicular Antibody, EV Displayed (VS-0425-YC465) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to EDNRA-expressed cells or tissues. The EDNRA is a receptor for endothelin-1, involved in vasoconstriction and linked to migraine resistance.

    Specific Inquiry
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/if_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human colon
    Figure 2 IHC staining of human colon
    (Immunohistochemical staining of human colon shows moderate positivity in glandular cells and endothelial cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/13774/33101_A_8_3_selected.jpg
    Figure 3 IHC staining of human duodenum
    Figure 3 IHC staining of human duodenum
    (Immunohistochemical staining of human duodenum shows disitnct cytoplasmic positivity in glandular and endothelial cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_7_2_selected.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_B_7_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Peripheral nerve/ganglion
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_8_3.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in glomeruli
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_9_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_4_6.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Non-germinal center cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_9_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HHSteC, LHCN-M2, SH-SY5Y)
    Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HHSteC, LHCN-M2, SH-SY5Y)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000151617-EDNRA

    Recombinant Antibody

    • Application
    • ELISA, FC, Cell-uptake
    • Product Type
    • Ab-Fc-EVs
    • Antibody Quantification (Ab/EV)
    • ~100 Ab/EV
    • Target
    • EDNRA
    • Host Animal
    • Mouse
    • Antibody Isotype
    • IgG
    • Species Reactivity
    • Human
    • Expression Cell
    • Mammalian cell

    Engineered EVs

    • EV-sorting domain
    • CD63
    • Fc-binding domain
    • Protein A
    • EV Size
    • 30~150 nm
    • Producing Cell
    • HEK293F
    • Isolation Method
    • Gradient centrifugation
    • Purification
    • qEV size exclusion chromatography
    • Concentration
    • 1 x 10¹⁰
    • Size
    • 1 mL
    • Buffer
    • PBS
    • Storage
    • Store at -80°C for 12 months

    Target

    • Full Name
    • Endothelin receptor type A
    • Molecular Function
    • G-protein coupled receptor, Receptor, Transducer
    • Cellular Localization
    • Plasma membrane, Cytosol
    • Introduction
    • This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance.
    • Alternative Names
    • ET-A, ETA-R, hET-AR

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    IgG Antibody Products ScFv Antibody Products Fab Antibody Products ScFv-Fc Chimera Products
    CAT Product Name Application Type
    MOB-1753z Mouse Anti-EDNRA Recombinant Antibody (clone 29C10) WB, IF, IP Mouse IgG1
    HPAB-N0077-YC Mouse Anti-EDNRA Recombinant Antibody (HPAB-N0077-YC) ELISA, FC, FuncS Mouse IgG

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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