Human Anti-EDNRA scFv-Fc Chimera (VS-0325-FY52) (CAT#: VS-0325-FY52)
The anti-EDNRA scFv-Fc antibody is a recombinant fusion protein designed to target the Endothelin Receptor Type A (EDNRA). This antibody leverages the single-chain variable fragment (scFv) format fused with an Fc domain, offering high specificity and affinity for its target. It is engineered for applications in research related to cardiovascular diseases and endothelial signaling pathways. The scFv-Fc format enhances stability and half-life, making it suitable for both in vitro and in vivo studies.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/if_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows moderate positivity in glandular cells and endothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13774/33101_A_8_3_selected.jpg
(Immunohistochemical staining of human colon shows moderate positivity in glandular cells and endothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13774/33101_A_8_3_selected.jpg
Figure 3 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows disitnct cytoplasmic positivity in glandular and endothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_7_2_selected.jpg
(Immunohistochemical staining of human duodenum shows disitnct cytoplasmic positivity in glandular and endothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_7_2_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_B_7_5.jpg
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_B_7_5.jpg
Figure 5 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_8_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_8_3.jpg
Figure 6 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_9_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_9_5.jpg
Figure 7 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_4_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_4_6.jpg
Figure 8 Lymph node
(Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_9_8.jpg
(Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_9_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HHSteC, LHCN-M2, SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000151617-EDNRA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000151617-EDNRA
Specifications
- Immunogen
- The immunogen is vesicle probes prepared from CHO cells displaying the ETaR GPCR.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human EDNRA
- Species Reactivity
- Human
- Applications
- Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- ETA; ET-A; ETAR; ETRA; MFDA; ETA-R; hET-AR
- Gene ID
- 1909
- UniProt ID
- P25101
- Long Name
- Endothelin Receptor Type A
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn29 and Asn62
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001159527.1; NP_001341726.1; NP_001948.1
- Function
- EDNRA (Endothelin receptor type A) is a G protein-coupled receptor that mediates the effects of endothelin-1. It plays a role in vasoconstriction and cell proliferation, and is implicated in cardiovascular diseases.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "EDNRA"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1753z | Mouse Anti-EDNRA Recombinant Antibody (clone 29C10) | WB, IF, IP | Mouse IgG1 |
| HPAB-N0077-YC | Mouse Anti-EDNRA Recombinant Antibody (HPAB-N0077-YC) | ELISA, FC, FuncS | Mouse IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0325-FY52. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, ELISA, FC, IHC, IP
Application: ELISA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, Cyt, PP, Inhib
-3.jpg)
Application: IB, FC, ELISA, FuncS
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
