Human Anti-EDNRA scFv-Fc Chimera (VS-0325-FY52)
CAT#: VS-0325-FY52
The anti-EDNRA scFv-Fc antibody is a recombinant fusion protein designed to target the Endothelin Receptor Type A (EDNRA). This antibody leverages the single-chain variable fragment (scFv) format fused with an Fc domain, offering high specificity and affinity for its target. It is engineered for applications in research related to cardiovascular diseases and endothelial signaling pathways. The scFv-Fc format enhances stability and half-life, making it suitable for both in vitro and in vivo studies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows moderate positivity in glandular cells and endothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13774/33101_A_8_3_selected.jpg
Normal Tissue
Figure 3 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows disitnct cytoplasmic positivity in glandular and endothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_7_2_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_8_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_4_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18957/41764_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HHSteC, LHCN-M2, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000151617-EDNRA
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Specifications
- Immunogen
- The immunogen is vesicle probes prepared from CHO cells displaying the ETaR GPCR.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human EDNRA
- Species Reactivity
- Human
- Applications
- Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- ETA; ET-A; ETAR; ETRA; MFDA; ETA-R; hET-AR
- Gene ID
- 1909
- UniProt ID
- P25101
- Long Name
- Endothelin Receptor Type A
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn29 and Asn62
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001159527.1; NP_001341726.1; NP_001948.1
- Function
- EDNRA (Endothelin receptor type A) is a G protein-coupled receptor that mediates the effects of endothelin-1. It plays a role in vasoconstriction and cell proliferation, and is implicated in cardiovascular diseases.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "EDNRA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1753z | Mouse Anti-EDNRA Recombinant Antibody (clone 29C10) | WB, IF, IP | Mouse IgG1 |
| HPAB-N0077-YC | Mouse Anti-EDNRA Recombinant Antibody (HPAB-N0077-YC) | ELISA, FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0077-YC-S(P) | Mouse Anti-EDNRA Recombinant Antibody; scFv Fragment (HPAB-N0077-YC-S(P)) | ELISA, FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0077-YC-F(E) | Mouse Anti-EDNRA Recombinant Antibody; Fab Fragment (HPAB-N0077-YC-F(E)) | ELISA, FC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC465 | Recombinant Anti-EDNRA Vesicular Antibody, EV Displayed (VS-0425-YC465) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2156 | Anti-EDNRA Immunohistochemistry Kit | IHC |
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