Recombinant Anti-EDNRB Vesicular Antibody, EV Displayed (VS-0425-YC362)
CAT#: VS-0425-YC362
The Recombinant Anti-EDNRB Vesicular Antibody, EV Displayed (VS-0425-YC362) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to EDNRB-expressed cells or tissues. The EDNRB is a GPCR activating calcium signaling pathways, with mutations linked to Hirschsprung disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17842/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows moderate cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27546/ihc_selected.jpg
Normal Tissue
Figure 3 Placenta
Trophoblastic cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27546/61972_A_1_7.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, ASC diff, SK-MEL-30, U-266/70, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000136160-EDNRB
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- EDNRB
- Host Animal
- Mouse
- Antibody Isotype
- IgG2b kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Endothelin receptor type B
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Plasma membrane, Cytosol
- Introduction
- The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
- Alternative Names
- ETB, HSCR, HSCR2
- Gene ID
- 1910
- UniProt ID
- P24530
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| MOR-1092 | Hi-Affi™ Rabbit Anti-EDNRB Recombinant Antibody (clone DS1092AB) | WB, ICC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0078-YC-S(P) | Mouse Anti-EDNRB Recombinant Antibody; scFv Fragment (HPAB-N0078-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-N0078-YC-F(E) | Mouse Anti-EDNRB Recombinant Antibody; Fab Fragment (HPAB-N0078-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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