SmartAb™ Recombinant Anti-EDNRB pH-dependent Antibody (Clone Rendomab-B1)
CAT#: VS-0825-YC106
The anti-EDNRB pH-dependent antibody (clone Rendomab-B1) is a pH-responsive antibody engineered to target human endothelin subtype B (EDNRB). This pH-switched monoclonal antibody (mAb) was developed by incorporating histidine residues into its variable regions, which results in pH-biased binding to EDNRB. By leveraging the natural pH variations in different tissues and cellular compartments, this pH-responsive antibody facilitates precise targeting of EDNRB on cells and tissues. Human endothelin subtype B (ETB) is a G protein-coupled receptor that binds to the peptide endothelin. It is involved in a variety of physiological processes, including blood pressure regulation and cell proliferation, and its dysfunction is linked to certain diseases like hypertension.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17842/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows moderate cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27546/ihc_selected.jpg
Normal Tissue
Figure 3 Placenta
Trophoblastic cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27546/61972_A_1_7.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, ASC diff, SK-MEL-30, U-266/70, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000136160-EDNRB
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2b kappa
- Specificity
- Human endothelin subtype B
- Species Reactivity
- Human
- Clone
- Rendomab-B1
- Applications
- ELISA, FC
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-302 | Recombinant Anti-human EDNRB Antibody | ELISA, WB, FuncS | IgG |
| MHH-302 | Recombinant Human Anti-human EDNRB Antibody | ELISA, IP, FuncS | IgG |
| MRO-0534-CN | Rabbit Anti-EDNRB Recombinant Antibody (clone JM74-10) | WB, IP | Rabbit IgG |
| HPAB-N0078-YC | Mouse Anti-EDNRB Recombinant Antibody (HPAB-N0078-YC) | ELISA, FC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-302-F(E) | Recombinant Anti-human EDNRB Antibody Fab Fragment | WB, FuncS | Fab |
| MHH-302-F(E) | Recombinant Human Anti-human EDNRB Antibody Fab Fragment | RIA, IP, FuncS | Fab |
| HPAB-N0078-YC-F(E) | Mouse Anti-EDNRB Recombinant Antibody; Fab Fragment (HPAB-N0078-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-302-S(P) | Recombinant Anti-human EDNRB Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| MHH-302-S(P) | Recombinant Human Anti-human EDNRB Antibody scFv Fragment | WB, IHC, FuncS | scFv |
| HPAB-N0078-YC-S(P) | Mouse Anti-EDNRB Recombinant Antibody; scFv Fragment (HPAB-N0078-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-013WM | Anti-Human EDNRB Recombinant Antibody (Rendomab-BI) | ELISA, FC | |
| TAB-013WM-S(P) | Anti-Human EDNRB Recombinant Antibody scFv Fragment (Rendomab-BI) | ELISA, FC | |
| TAB-013WM-F(E) | Anti-Human EDNRB Recombinant Antibody Fab Fragment (Rendomab-BI) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1092 | Hi-Affi™ Rabbit Anti-EDNRB Recombinant Antibody (clone DS1092AB) | WB, ICC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC362 | Recombinant Anti-EDNRB Vesicular Antibody, EV Displayed (VS-0425-YC362) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2157 | Anti-EDNRB Immunohistochemistry Kit | IHC |
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