Recombinant Anti-ENTPD1 Vesicular Antibody, EV Displayed (VS-0425-YC617) (CAT#: VS-0425-YC617)
The Recombinant Anti-ENTPD1 Vesicular Antibody, EV Displayed (VS-0425-YC617) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ENTPD1-expressed cells or tissues. ENTPD1 hydrolyzes extracellular ATP to AMP, with inhibition offering potential anticancer benefits.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression

Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/if_selected.jpg

Figure 2 IHC staining of human endometrium
(Immunohistochemical staining of human endometrium shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79986/170655_B_5_3_selected.jpg
(Immunohistochemical staining of human endometrium shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79986/170655_B_5_3_selected.jpg

Figure 3 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_B_7_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_B_7_5.jpg

Figure 4 Colon
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Fibroblasts
Staining: Medium
Intensity: Moderate
Mucosal lymphoid cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_3.jpg
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Fibroblasts
Staining: Medium
Intensity: Moderate
Mucosal lymphoid cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_3.jpg

Figure 5 Placenta
(Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_1_7.jpg
(Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_1_7.jpg

Figure 6 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_8.jpg

Figure 7 RNA cell line category: Group enriched (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138185-ENTPD1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138185-ENTPD1
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ENTPD1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Ectonucleoside triphosphate diphosphohydrolase 1
- Molecular Function
- Hydrolase
- Cellular Localization
- Microtubules
- Introduction
- The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits.
- Alternative Names
- ATPDase, CD39, NTPDase-1, SPG64
- Gene ID
- 953
- UniProt ID
- P49961
Downloads
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