Recombinant Anti-ENTPD1 Vesicular Antibody, EV Displayed (VS-0425-YC617) (CAT#: VS-0425-YC617)
The Recombinant Anti-ENTPD1 Vesicular Antibody, EV Displayed (VS-0425-YC617) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ENTPD1-expressed cells or tissues. ENTPD1 hydrolyzes extracellular ATP to AMP, with inhibition offering potential anticancer benefits.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/if_selected.jpg
Figure 2 IHC staining of human endometrium
(Immunohistochemical staining of human endometrium shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79986/170655_B_5_3_selected.jpg
(Immunohistochemical staining of human endometrium shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79986/170655_B_5_3_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_B_7_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_B_7_5.jpg
Figure 4 Colon
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Fibroblasts
Staining: Medium
Intensity: Moderate
Mucosal lymphoid cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_3.jpg
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Fibroblasts
Staining: Medium
Intensity: Moderate
Mucosal lymphoid cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_3.jpg
Figure 5 Placenta
(Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_1_7.jpg
(Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Hofbauer cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_1_7.jpg
Figure 6 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14067/31810_A_9_8.jpg
Figure 7 RNA cell line category: Group enriched (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138185-ENTPD1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138185-ENTPD1
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ENTPD1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Ectonucleoside triphosphate diphosphohydrolase 1
- Molecular Function
- Hydrolase
- Cellular Localization
- Microtubules
- Introduction
- The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits.
- Alternative Names
- ATPDase, CD39, NTPDase-1, SPG64
- Gene ID
- 953
- UniProt ID
- P49961
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1158 | Hi-Affi™ Rabbit Anti-ENTPD1 Recombinant Antibody (clone DS1158AB) | WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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