Recombinant Anti-F2RL1 Vesicular Antibody, EV Displayed (VS-0425-YC284)
CAT#: VS-0425-YC284
The Recombinant Anti-F2RL1 Vesicular Antibody, EV Displayed (VS-0425-YC284) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to F2RL1-expressed cells or tissues. The F2RL1 is a GPCR, and its activation affects vascular muscle relaxation, blood pressure regulation, and immunity, playing roles in inflammation and dilating blood flow.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14091/1740_E4_17_cr57fce65847914_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12989/33496_B_8_5.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12989/33496_A_5_1.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12989/33496_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12989/33496_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12989/33496_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12989/33496_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12989/33496_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (PC-3, RPTEC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164251-F2RL1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- F2RL1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Monkey
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- F2R like trypsin receptor 1
- Biological Process
- Immunity, Inflammatory response, Innate immunity
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity.
- Alternative Names
- GPR11, PAR2
- Gene ID
- 2150
- UniProt ID
- P55085
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1591z | Mouse Anti-F2RL1 Recombinant Antibody (clone 38D1) | WB, FC, IF, IHC, IP | Mouse IgG2a, κ |
| HPAB-0363-CN | Human Anti-F2RL1 Recombinant Antibody (HPAB-0363-CN) | WB, FC, Block | Human IgG |
| HPAB-0364-CN | Human Anti-F2RL1 Recombinant Antibody (HPAB-0364-CN) | WB, FC, Block | Human IgG |
| HPAB-1526-FY | Human Anti-F2RL1 Recombinant Antibody (clone Ab3777) | Block | Human IgG |
| VS11-QX64 | Human Anti-F2RL1 Recombinant Antibody (clone Ab4999) | ELISA | Human IgG4, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0934CL | Human Anti-F2RL1 Recombinant Antibody (TAB-0934CL) | ELISA, RIA, FC | Human IgG, κ |
| TAB-0935CL | Human Anti-F2RL1 Recombinant Antibody (TAB-0935CL) | ELISA, RIA, FC | Human IgG, κ |
| TAB-0934CL-S(P) | Human Anti-F2RL1 Recombinant Antibody; scFv Fragment (TAB-0934CL-S(P)) | ELISA, RIA, FC | Human scFv |
| TAB-0934CL-F(E) | Human Anti-F2RL1 Recombinant Antibody; Fab Fragment (TAB-0934CL-F(E)) | ELISA, RIA, FC | Human Fab |
| TAB-0935CL-F(E) | Human Anti-F2RL1 Recombinant Antibody; Fab Fragment (TAB-0935CL-F(E)) | ELISA, RIA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0610CLV | Mouse Anti-F2RL1 Recombinant Antibody (TAB-0610CLV) | Inhib, IF, WB | Mouse IgG |
| TAB-0610CLV-F(E) | Mouse Anti-F2RL1 Recombinant Antibody; Fab Fragment (TAB-0610CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0610CLV-S(P) | Mouse Anti-F2RL1 Recombinant Antibody; scFv Fragment (TAB-0610CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0363-CN-S(P) | Human Anti-F2RL1 Recombinant Antibody; scFv Fragment (HPAB-0363-CN-S(P)) | WB, FC, Block | Human scFv |
| HPAB-0364-CN-S(P) | Human Anti-F2RL1 Recombinant Antibody; scFv Fragment (HPAB-0364-CN-S(P)) | WB, FC, Block | Human scFv |
| HPAB-1526-FY-F(E) | Human Anti-F2RL1 Recombinant Antibody (clone Ab3777); scFv Fragment | Block | Human scFv |
| HPAB-1527-FY-F(E) | Human Anti-F2RL1 Recombinant Antibody (clone Ab4213); scFv Fragment | Block | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0363-CN-F(E) | Human Anti-F2RL1 Recombinant Antibody; Fab Fragment (HPAB-0363-CN-F(E)) | WB, FC, Block | Human Fab |
| HPAB-0364-CN-F(E) | Human Anti-F2RL1 Recombinant Antibody; Fab Fragment (HPAB-0364-CN-F(E)) | WB, FC, Block | Human Fab |
| HPAB-1526-FY-S(P) | Human Anti-F2RL1 Recombinant Antibody (clone Ab3777); Fab Fragment | Block | Human Fab |
| HPAB-1527-FY-S(P) | Human Anti-F2RL1 Recombinant Antibody (clone Ab4213); Fab Fragment | Block | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY119 | Human Anti-F2RL1 (clone Ab4999) scFv-Fc Chimera | Block, ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC371 | CytoStream™ Rabbit Anti-F2RL1 Recombinant Antibody (VS13-YC371) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2410 | Anti-F2RL1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2411 | Anti-Mouse F2RL1 Immunohistochemistry Kit | IHC |
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