Human Anti-F2RL1 (clone Ab4999) scFv-Fc Chimera (CAT#: VS-0325-FY119)

• Immunogen
• The initial antibody was generated through phage display methods to identify Fab fragments that specifically bind to the residues surrounding the protease cleavage site at the N-terminal of PAR-2.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• This antibody exhibits binding specificity for the N-terminal peptide of PAR-2.

• Species Reactivity
• Human

• Clone
• Ab4999

• Applications
• Blocking, ELISA

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• F2R Like Trypsin Receptor 1; Coagulation Factor II (Thrombin) Receptor-Like 1; G-Protein Coupled Receptor 11; Thrombin Receptor-Like 1; GPR11; PAR2

• Gene ID
• 2150

• UniProt ID
• P55085

• Long Name
• F2R Like Trypsin Receptor 1

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• N-glycosylated and sialylated.
  Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.
  Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes.
  Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation.
  Glycosylation at Asn30, Thr45, Ser46, Thr49, Thr54, and Asn222
  Ubiquitination at Lys368
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 7 sites, 1 O-linked glycan (5 sites)

• Protein Refseq
• NP_005233.4

• Function
• Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection.
  Generally is promoting inflammation.
  Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling.
  Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X.
  Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3.

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

• VS11-QX64
• Human Anti-F2RL1 Recombinant Antibody (clone Ab4999)

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