Recombinant Anti-FASLG Vesicular Antibody, EV Displayed (VS-0425-YC618)

Name: Recombinant Anti-FASLG Vesicular Antibody, EV Displayed (VS-0425-YC618)
SKU: VS-0425-YC618
Rating: 5 (1 reviews)

CAT#: VS-0425-YC618

The Recombinant Anti-FASLG Vesicular Antibody, EV Displayed (VS-0425-YC618) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FASLG-expressed cells or tissues. FASLG is part of the TNF superfamily, crucial for apoptosis induction in T cells. It plays roles in immune regulation and some cancers' progression.

Gene Expression

Normal Tissue Figure 1 IHC staining of human lymph node

Immunohistochemical staining of human lymph node shows distinct cytoplasmic positivity in subsets of cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54959/ihc_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54959/134178_B_8_5.jpg

Normal Tissue Figure 3 Kidney

Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54959/134178_A_8_5.jpg

Normal Tissue Figure 4 Testis

Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54959/134178_A_6_6.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54959/134178_B_5_4.jpg

Normal Tissue Figure 6 Lymph node

Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54959/134178_A_8_8.jpg

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Recombinant Antibody

Application
ELISA, FC, Neut, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
FASLG

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Fas ligand

Biological Process
Apoptosis, Transcription, Transcription regulation

Molecular Function
Cytokine, Repressor

Introduction
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

Alternative Names
APT1LG1, CD178, FasL, TNFSF6

Gene ID
356

UniProt ID
P48023

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Datasheet

Datasheet - VS-0425-YC618.pdf

MSDS

MSDS - VS-0425-YC618.pdf

COA

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