Recombinant Anti-FZD2 Vesicular Antibody, EV Displayed (VS-0425-YC342) (CAT#: VS-0425-YC342)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• FZD2

• Host Animal
• Human

• Antibody Isotype
• IgG1

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Frizzled class receptor 2

• Biological Process
• Wnt signaling pathway

• Molecular Function
• Developmental protein, G-protein coupled receptor, Receptor, Transducer

• Cellular Localization
• Nucleoplasm, Nuclear bodies, Cell Junctions, Actin filaments, Basal body

• Introduction
• This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

• Gene ID
• 2535

• UniProt ID
• Q14332

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