Anti-Human GAD2 Recombinant Antibody
CAT#: TAB-0386CL
The anti-GAD65 antibody specifically bind to the epitope of giutamate decarboxylase, and can be used for delaying the onset of Type 1 diabetes, and for inhibiting insulitis and other diabetic symptoms, for detecting susceptibility to Type 1 diabetes
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm, nuclear bodies & cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/1240_D11_7_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human heart muscle
Immunohistochemical staining of human heart muscle shows moderate cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm & nuclear bodies.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/991_A9_8_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nuclear bodies.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/983_A9_1_red_green.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/131007_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/131007_A_7_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/131007_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/131007_A_6_6.jpg
Normal Tissue
Figure 9 Heart muscle
Cardiomyocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/131007_B_5_6.jpg
Normal Tissue
Figure 10 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57667/131007_A_8_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000180340-FZD2
❮
❯
Specifications
- Host Species
- Human
- Type
- Human antibody
- Antibody Isotype
- IgG1
- Specificity
- Human
- Related Disease
- Type 1 diabetes, insulitis
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for TAB-0386CL. Click the button above to contact us or submit your feedback about this product.
Specific For GAD65 Epitope
Despite the catalog symbol confusion, this antibody specifically binds to the glutamate decarboxylase (GAD65) epitope as described in the text. We used it for research into Type 1 diabetes autoantigens, and it showed strong reactivity in our ELISA panels.
Useful For Insulitis Research
We utilized this recombinant antibody to study markers associated with insulitis. It specifically recognizes the target antigen effectively. The antibody has been a valuable component of our research into the onset mechanisms of diabetic symptoms in human models.
Q&As
-
What target does this antibody specifically bind to?
A: This antibody specifically binds to the epitope of glutamate decarboxylase (GAD65), also known as GAD2. It recognizes this major autoantigen which is relevant for research into Type 1 diabetes and insulin-dependent diabetes mechanisms.
-
What are the potential research applications for this antibody?
A: This antibody can be used for research applications such as ELISA and Western Blot. It is useful for studies aiming to detect susceptibility to Type 1 diabetes, delaying its onset, or inhibiting insulitis in research models.
View the frequently asked questions answered by Creative Biolabs Support.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Fzd2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1042-VHH | Recombinant Anti-Human Fzd2 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2608z | Mouse Anti-FZD2 Recombinant Antibody (clone 9G6) | ELISA, WB | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0386CL-S(P) | Anti-Human FZD2 Recombinant Antibody scFv Fragment | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0386CL-F(E) | Anti-Human FZD2 Recombinant Antibody Fab Fragment | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0748CT | Recombinant Mouse anti-Human FZD2 Monoclonal antibody (EML2217) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC342 | Recombinant Anti-FZD2 Vesicular Antibody, EV Displayed (VS-0425-YC342) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC143 | SmartAb™ Recombinant Anti-FZD2 pH-dependent Antibody (VS-0825-YC143) | ELISA | Human IgG |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: Neut, ELISA, Inhib, ICC, WB
Application: WB, IF, FuncS
Application: ELISA, SPR, Inhib, FuncS
Application: ELISA, Inhib, FC
Application: ELISA
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: ELISA, IHC, IF, IP, FC, FuncS
Application: ELISA, FC, IHC, Neut
-3.jpg)
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
