Recombinant Anti-GJA1 Vesicular Antibody, EV Displayed (VS-0425-YC474)
CAT#: VS-0425-YC474
The Recombinant Anti-GJA1 Vesicular Antibody, EV Displayed (VS-0425-YC474) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GJA1-expressed cells or tissues. The GJA1 is a gap junction protein critical for heart function and development, with mutations linked to several disorders.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to cell junctions & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47551/1786_D4_6_selected.jpg
Normal Tissue
Figure 2 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10753/26414_A_6_6.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10753/26414_B_8_5.jpg
Normal Tissue
Figure 4 Parathyroid gland
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10753/26414_A_2_8.jpg
Normal Tissue
Figure 5 Colon
Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10753/26414_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10753/26414_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (hTERT-RPE1, HUVEC TERT2, NTERA-2, SuSa, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000152661-GJA1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GJA1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Gap junction protein alpha 1
- Cellular Localization
- Vesicles, Cell Junctions, Nucleoplasm
- Introduction
- This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]
- Alternative Names
- CX43, GJAL, ODD, ODDD, ODOD, SDTY3
- Gene ID
- 2697
- UniProt ID
- P17302
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Datasheet
MSDS
COA
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See other products for "GJA1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2247z | Mouse Anti-GJA1 Recombinant Antibody (clone 38A10) | FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2457CT | Recombinant Mouse anti-Human GJA1 Monoclonal antibody (3E5) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1445 | Hi-Affi™ Rabbit Anti-GJA1 Recombinant Antibody (clone DS1445AB) | ELISA, ICC, IF, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1784-CN | Rabbit Anti-GJA1 Polyclonal Antibody (MRO-1784-CN) | WB, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0496-YC | Mouse Anti-GJA1 Recombinant Antibody (HPAB-M0496-YC) | IHC, Inhib, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0497-YC | Mouse Anti-GJA1 Recombinant Antibody (HPAB-M0497-YC) | IHC, Inhib, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0496-YC-S(P) | Mouse Anti-GJA1 Recombinant Antibody; scFv Fragment (HPAB-M0496-YC-S(P)) | IHC, Inhib, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0497-YC-S(P) | Mouse Anti-GJA1 Recombinant Antibody; scFv Fragment (HPAB-M0497-YC-S(P)) | IHC, Inhib, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0496-YC-F(E) | Mouse Anti-GJA1 Recombinant Antibody; Fab Fragment (HPAB-M0496-YC-F(E)) | IHC, Inhib, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0497-YC-F(E) | Mouse Anti-GJA1 Recombinant Antibody; Fab Fragment (HPAB-M0497-YC-F(E)) | IHC, Inhib, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0088-FY | Rabbit Anti-GJA1 Recombinant Antibody (clone AFY0059) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY918 | Anti-GJA1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2811 | Anti-Mouse GJA1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2810 | Anti-Human GJA1 Immunohistochemistry Kit | IHC |
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