Recombinant Anti-GLRA1 Vesicular Antibody, EV Displayed (VS-0425-YC64) (CAT#: VS-0425-YC64)

The Recombinant Anti-GLRA1 Vesicular Antibody, EV Displayed (VS-0425-YC64) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GLRA1-expressed cells or tissues. The GLRA1 is a glycine receptor subunit involved in inhibitory synapse functions, with mutations leading to startle disease.

Specific Inquiry
  • Datasheet
  • MSDS
  • COA

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • GLRA1
  • Host Animal
  • Rabbit
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human, Rat, Mouse, Pig, Zebrafish
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Glycine receptor alpha 1
  • Biological Process
  • Ion transport, Transport
  • Molecular Function
  • Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
  • Cellular Localization
  • Vesicles, Plasma membrane
  • Introduction
  • The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found.
  • Alternative Names
  • STHE

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