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GLRA1
Loading...Anti-GLRA1 Products
- Recombinant Mouse Anti-Human GLRA1 Antibody (MOB-0584MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Rabbit Anti-GLRA1 Recombinant Antibody (VS-0223-WK34) (VS-0223-WK34)
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- Derivation: Rabbit
- Species Reactivity: Human, Rat, Mouse, Pig, Zebrafish
- Type: Rabbit IgG
- Application: WB, ICC, IHC, IHC-P
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- Guinea pig Anti-GLRA1 Recombinant Antibody (VS-0223-WK35) (VS-0223-WK35)
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- Derivation: Guinea pig
- Species Reactivity: Human, Rat, Mouse, Pig, Zebrafish
- Type: Guinea pig IgG
- Application: WB, IHC
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- Rabbit Anti-GLRA1 Recombinant Antibody (VS-0223-WK36) (VS-0223-WK36)
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- Derivation: Rabbit
- Species Reactivity: Human, Rat, Mouse, Pig, Zebrafish
- Type: Rabbit IgG
- Application: ICC, IHC
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- Mouse Anti-GLRA1 Recombinant Antibody (clone 7F8E2) (VS7-HM1008)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Bipolar cells, Inhibitory neurons, Excitatory neurons, Horizontal cells, Oligodendrocyte precursor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Homopentamer (in vitro) (PubMed:22715885, PubMed:22973015, PubMed:23994010, PubMed:25730860). Interacts with GLRB to form heteropentameric channels; this is probably the predominant form in vivo (PubMed:22715885, PubMed:22973015, PubMed:25445488). Heteropentamer composed of two GLRA1 and three GLRB (PubMed:22715885). Heteropentamer composed of three GLRA1 and two GLRB (PubMed:22973015). Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed:14551753, PubMed:22715885, PubMed:22973015, PubMed:25445488, PubMed:23994010, PubMed:25730860).
Molecular function
Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
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