Recombinant Anti-GYPA Vesicular Antibody, EV Displayed (VS-0425-YC723)
CAT#: VS-0425-YC723
The Recombinant Anti-GYPA Vesicular Antibody, EV Displayed (VS-0425-YC723) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GYPA-expressed cells or tissues. GYPA and GYPB encode erythrocyte membrane sialoglycoproteins bearing MN and Ss blood group antigens, with numerous variant phenotypes from gene recombinations.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14811/1848_C4_22_cr5ac318c11ea41_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows cytoplasmic positivity in erythrocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14811/34109_B_6_4_selected.jpg
Normal Tissue
Figure 3 High expression in bone marrow.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2658/6543_B_5_4_val_selected.jpg
Normal Tissue
Figure 4 Low expression in prostate.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2658/6543_A_2_5_val_selected.jpg
Normal Tissue
Figure 5 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2658/6543_B_6_4.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (HEL, K-562)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000170180-GYPA
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GYPA
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Glycophorin A (MNS blood group)
- Biological Process
- Host-virus interaction
- Molecular Function
- Blood group antigen, Host cell receptor for virus entry, Receptor
- Cellular Localization
- Nucleoplasm, Plasma membrane, Cytosol
- Introduction
- Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
- Alternative Names
- CD235a, GPA, MN, MNS
- Gene ID
- 2993
- UniProt ID
- P02724
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Datasheet
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COA
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