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    GYPA

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    Anti-GYPA Products

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    For Research Use Only. Not For Clinical Use.


    Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
    Protein class

    Blood group antigen proteins, CD markers

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enriched (Erythroid cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Group enriched (HEL, K-562)

    Interaction

    Homodimer. (Microbial infection) Interacts with Streptococcus gordonii hsa protein.

    Molecular function

    Blood group antigen, Host cell receptor for virus entry, Receptor

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