Recombinant Anti-IL17RB Vesicular Antibody, EV Displayed (VS-0425-YC493)
CAT#: VS-0425-YC493
The Recombinant Anti-IL17RB Vesicular Antibody, EV Displayed (VS-0425-YC493) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL17RB-expressed cells or tissues. IL17RB is a cytokine receptor for IL17B and IL17E and mediates immune responses like NF-kappaB activation. Expression of IL17RB is upregulated during inflammation, suggesting immunoregulatory roles.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line OE19
Immunofluorescent staining of human cell line OE19 shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5482/2038_F4_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5482/15814_B_7_5.jpg
Normal Tissue
Figure 3 Adrenal gland
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5482/15814_B_4_5.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5482/15814_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Distal tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Proximal tubules (cell body)
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5482/15814_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5482/15814_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000056736-IL17RB
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL17RB
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 17 receptor B
- Molecular Function
- Receptor
- Cellular Localization
- Vesicles, Plasma membrane
- Introduction
- The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
- Alternative Names
- CRL4, EVI27, IL17BR, IL17RH1
- Gene ID
- 55540
- UniProt ID
- Q9NRM6
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Datasheet
MSDS
COA
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See other products for "IL17RB"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1426-VHH | Recombinant Anti-Human IL17RB VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0228CT | Recombinant Mouse anti-Human IL17RB Monoclonal antibody (08D702) | WB | |
| MRO-1965-CN | Rabbit Anti-IL17RB Polyclonal Antibody (MRO-1965-CN) | WB | Rabbit IgG |
| HPAB-0290-YJ | Mouse Anti-IL17RB Recombinant Antibody (HPAB-0290-YJ) | ELISA, IHC, FC, Neut, Block | Mouse IgG |
| HPAB-0291-YJ | Human Anti-IL17RB Recombinant Antibody (HPAB-0291-YJ) | ELISA, IHC, FC, Neut, Block | Chimeric (Mouse/Human) IgG |
| HPAB-AP684-YC | Mouse Anti-IL17RB Recombinant Antibody (HPAB-AP684-YC) | Neut, FuncS, IHC, ELISA, FC, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1236CQ | Mouse Anti-IL17RB Recombinant Antibody (clone CBL099) | WB, Neut | Mouse IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0290-YJ-S(P) | Mouse Anti-IL17RB Recombinant Antibody; scFv Fragment (HPAB-0290-YJ-S(P)) | ELISA, IHC, FC, Neut, Block | Mouse scFv |
| HPAB-0291-YJ-S(P) | Mouse Anti-IL17RB Recombinant Antibody; scFv Fragment (HPAB-0291-YJ-S(P)) | ELISA, IHC, FC, Neut, Block | Mouse scFv |
| HPAB-AP684-YC-S(P) | Mouse Anti-IL17RB Recombinant Antibody; scFv Fragment (HPAB-AP684-YC-S(P)) | ELISA, FC, Inhib, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0290-YJ-F(E) | Mouse Anti-IL17RB Recombinant Antibody; Fab Fragment (HPAB-0290-YJ-F(E)) | ELISA, IHC, FC, Neut, Block | Mouse Fab |
| HPAB-0291-YJ-F(E) | Human Anti-IL17RB Recombinant Antibody; Fab Fragment (HPAB-0291-YJ-F(E)) | ELISA, IHC, FC, Neut, Block | Human Fab |
| HPAB-AP684-YC-F(E) | Mouse Anti-IL17RB Recombinant Antibody; Fab Fragment (HPAB-AP684-YC-F(E)) | ELISA, FC, Inhib, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3497 | Anti-IL17RB Immunohistochemistry Kit | IHC |
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