Recombinant Anti-IL18RAP Vesicular Antibody, EV Displayed (VS-0425-YC418)
CAT#: VS-0425-YC418
The Recombinant Anti-IL18RAP Vesicular Antibody, EV Displayed (VS-0425-YC418) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL18RAP-expressed cells or tissues. The IL18RAP is a receptor accessory subunit for IL18, involved in inflammatory responses and linked to diseases like Crohn's.
Gene Expression
Normal Tissue
Figure 1 Bone marrow
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161339_B_4_4_val_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161421_A_7_8.jpg
Normal Tissue
Figure 3 Tonsil
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161421_A_6_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115607-IL18RAP
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL18RAP
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 18 receptor accessory protein
- Biological Process
- Inflammatory response
- Molecular Function
- Hydrolase, Receptor
- Introduction
- The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
- Alternative Names
- AcPL, CD218b
- Gene ID
- 8807
- UniProt ID
- O95256
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
| MOB-1928z | Mouse Anti-IL18RAP Recombinant Antibody (clone 22B8) | WB, IHC, FuncS | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0234CT | Recombinant Mouse anti-Human IL18RAP Monoclonal antibody (EML2092) | WB |
| CAT | Product Name | Application | Type |
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| NEUT-1251CQ | Mouse Anti-IL18RAP Recombinant Antibody (clone CBL328) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1252CQ | Mouse Anti-IL18RAP Recombinant Antibody (NEUT-1252CQ) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1253CQ | Mouse Anti-IL18RAP Recombinant Antibody (clone CBL120) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0032 | Human Anti-IL18RAP Recombinant Antibody (clone 3131) | ELISA, Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0032-S(P) | Human Anti-IL18RAP Recombinant Antibody (clone 3131); scFv Fragment | ELISA, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0032-F(E) | Human Anti-IL18RAP Recombinant Antibody (clone 3131); Fab fragment | ELISA, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY5 | Human Anti-IL18RAP scFv-Fc Chimera (VS-0425-FY5) | Block, ELISA, IF, FC | Human IgG1, scFv-Fc |
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