Human Anti-IL18RAP scFv-Fc Chimera (VS-0425-FY5) (CAT#: VS-0425-FY5)
This product can be utilized in research to study the role of IL18RAP in immune responses, as well as in therapeutic developments for conditions associated with dysregulated IL-18 signaling, including autoimmune diseases, chronic inflammation, and certain cancers.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Bone marrow
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161339_B_4_4_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161339_B_4_4_val_selected.jpg
Figure 2 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161421_A_7_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161421_A_7_8.jpg
Figure 3 Tonsil
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161421_A_6_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25270/161421_A_6_8.jpg
Figure 4 RNA cell line category: Cell line enriched (U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115607-IL18RAP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115607-IL18RAP
Specifications
- Immunogen
- The immunogen was human IL-18Rβ.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL18RAP
- Species Reactivity
- Human
- Applications
- Blocking, ELISA, Immunofluorescence, Flow Cytometry
- Related Disease
- Crohn's disease and inflammatory bowel disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 18 Receptor Accessory Protein
- Gene ID
- 8807
- UniProt ID
- O95256
- Long Name
- Interleukin 18 Receptor Accessory Protein
- Sequence Similarities
- Belongs to the interleukin-1 receptor family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated.
Glycosylation at Asn152, Asn21, Asn119, and Asn345
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites
- Protein Refseq
- XP_011510390.1; XP_024308965.1; XP_024308966.1; XP_024308967.1; XP_024308969.1
- Function
- Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1928z | Mouse Anti-IL18RAP Recombinant Antibody (clone 22B8) | WB, IHC, FuncS | Mouse IgG1 |
| MOB-0234CT | Recombinant Mouse anti-Human IL18RAP Monoclonal antibody (EML2092) | WB | |
| PABJ-0032 | Human Anti-IL18RAP Recombinant Antibody (clone 3131) | ELISA, Inhib | Human IgG |
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For Research Use Only. Not For Clinical Use.
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