Recombinant Anti-ITGA3 Vesicular Antibody, EV Displayed (VS-0425-YC678)
CAT#: VS-0425-YC678
The Recombinant Anti-ITGA3 Vesicular Antibody, EV Displayed (VS-0425-YC678) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGA3-expressed cells or tissues. ITGA3 is an integrin alpha chain involved in cell adhesion, forming an integrin with beta 1 to interact with extracellular matrix proteins. It is associated with metastasis in breast cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18594/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18594/204_G7_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18594/203_G7_1_blue_red_green.jpg
Normal Tissue
Figure 4 Lung
Alveolar cells type I
Staining: High
Intensity: Strong
Quantity: 75%-25%
Alveolar cells type II
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_2_4.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8572/23996_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HBEC3-KT, hTERT-RPE1, RPTEC TERT1, U-87 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005884-ITGA3
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGA3
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Monkey
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit alpha 3
- Biological Process
- Cell adhesion
- Molecular Function
- Integrin, Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
- Alternative Names
- CD49c, GAP-B3, MSK18, VCA-2, VLA3a
- Gene ID
- 3675
- UniProt ID
- P26006
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1157z | Mouse Anti-ITGA3 Recombinant Antibody (clone 20D11) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| HPAB-1659LY | Mouse Anti-ITGA3 Recombinant Antibody (HPAB-1659LY) | ELISA | Mouse IgG |
| ZG-0963F | Mouse Anti-ITGA3 Recombinant Antibody (clone 158A3) | ICC, IHC-Fr, WB | Mouse IgG2a |
| ZG-0976F | Mouse Anti-ITGA3 Recombinant Antibody (clone 29A3) | ICC, IHC-Fr, WB | Mouse IgG1 |
| ZG-1072F | Mouse Anti-ITGA3 Recombinant Antibody (clone PB36) | ICC, IHC-Fr, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0294MZ | Chicken Anti-ITGA3 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-CN-S(P) | Human Anti-ITGA3 Recombinant Antibody; scFv Fragment (HPAB-0016-CN-S(P)) | ELISA | Human scFv |
| HPAB-0017-CN-S(P) | Human Anti-ITGA3 Recombinant Antibody; scFv Fragment (HPAB-0017-CN-S(P)) | ELISA | Human scFv |
| HPAB-0018-CN-S(P) | Mouse Anti-ITGA3 Recombinant Antibody (clone ITGa3-VM2); scFv Fragment | IF, ELISA, IP | Mouse scFv |
| HPAB-1659LY-S(P) | Mouse Anti-ITGA3 Recombinant Antibody; scFv Fragment (HPAB-1659LY-S(P)) | ELISA | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-CN-F(E) | Human Anti-ITGA3 Recombinant Antibody; Fab Fragment (HPAB-0016-CN-F(E)) | ELISA | Human Fab |
| HPAB-0017-CN-F(E) | Human Anti-ITGA3 Recombinant Antibody; Fab Fragment (HPAB-0017-CN-F(E)) | ELISA | Human Fab |
| HPAB-0018-CN-F(E) | Mouse Anti-ITGA3 Recombinant Antibody (clone ITGa3-VM2); Fab Fragment | IF, ELISA, IP | Mouse Fab |
| HPAB-1659LY-F(E) | Mouse Anti-ITGA3 Recombinant Antibody; Fab Fragment (HPAB-1659LY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1461-FY | Recombinant Anti-ITGA3 Single Domain Antibody (HPAB-1461-FY) | ELISA, FC | Llama VHH |
| HPAB-0778-YJ-VHH | Camelid Anti-ITGA3 Recombinant Single Domain Antibody (HPAB-0778-YJ-VHH) | ELISA, Inhib | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1154 | Anti-ITGA3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3622 | Anti-Human ITGA3 Immunohistochemistry Kit | IHC |
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